Results 101 to 110 of about 1,318,364 (217)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

How Uncertainty Affects Children's Exploration and Exploitation in Statistical Learning. [PDF]

Dev Sci
Tong SX, Zhang P, Zhou M, Ziegler JC.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A simulation-based hybrid causal predictive framework for stockout risk analysis in supply chain. [PDF]

PLoS One
Hafaf E, Alzubi AB, Iyiola K, Aljuhmani HY.   +3 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Blood-based kinase activity profiling to predict response to immune checkpoint inhibitors in patients with advanced stage NSCLC: the prospective IOpener study. [PDF]

J Immunother Cancer
de Joode K, Groen HJ, Heuvel MVD, Kloover JS, Van Der Meer F, Van der Leest CH, Van Den Borne B, De Wijn R, Hurkmans DP, Van den Heuvel DMA, Pinedo HM, Kapiteijn E, Debets R, Verdegaal EME, Van der Burg SH, Groten JP, Aerts JGJV, Mathijssen RHJ.   +17 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Predictive performance precision analysis in medicine: identification of low-confidence predictions at patient and profile levels (MED3pa I). [PDF]

J Am Med Inform Assoc
Lefebvre O, Camirand Lemyre F, Ethier JF, Chikouche LH, Amriou L, Poenaru D, Vallières M.   +6 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Demonstration of efficient predictive surrogates for large-scale quantum processors. [PDF]

Nat Commun
Liao WY, Du Y, Wang X, Tian TC, Luo Y, Du B, Tao D, Huang HL.   +7 more
europepmc   +1 more source