Results 121 to 130 of about 2,534,918 (292)

Nonparametric Predictive Inference for Acceptance Decisions [PDF]

, 2011
This thesis presents new solutions for two acceptance decisions problems. First, we present methods for basic acceptance sampling for attributes, based on the nonparametric predictive inferential approach for Bernoulli data, which is extended for this ...
ELSAEITI, MOHAMED
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Biomolecular Factors Represented by Bcl-2, p53, and Tumor-Infiltrating Lymphocytes Predict Response for Adjuvant Anthracycline Chemotherapy in Patients with Early Triple-Negative Breast Cancer

Cancer Management and Research, 2020
Xenia Elena Bacinschi,1,2 Anca Zgura,2 Inga Safta,3 Rodica Anghel1,2 1Department of Oncology-Radiotherapy, Institute of Oncology Prof. Dr. Alexandru Trestioreanu, Bucharest, Romania; 2University of Medicine and Pharmacy Carol Davila, Bucharest, Romania ...
Bacinschi XE, Zgura A, Safta I, Anghel R
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

To Explain or To Predict?

SSRN Electronic Journal, 2010
Statistical modeling is a powerful tool for developing and testing theories by way of causal explanation, prediction, and description. In many disciplines there is near-exclusive use of statistical modeling for causal explanation and the assumption that models with high explanatory power are inherently of high predictive power.
openaire   +4 more sources

Predictive Probability Density Mapping for Search and Rescue Using an Agent-Based Approach With Sparse Data

IEEE Access
Predicting the location where a lost person could be found is crucial for search and rescue operations with limited resources. To improve the precision and efficiency of these predictions, simulated agents can be created to emulate the behavior of the ...
Jan-Hendrik Ewers, David Anderson, Douglas Thomson   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Quasi-continuous exhaust operational space

Nuclear Fusion
The IPED predictive pedestal code has been used to determine the critical gradients for the onset of 1) separatrix ballooning modes and 2) global peeling-ballooning modes as a function of plasma shaping.
M. Dunne, M. Faitsch, L. Radovanovic, E. Wolfrum, the ASDEX Upgrade Team   +4 more
doaj   +1 more source

The prognostic and predictive value of peripheral immune-related proteins in patients with lung cancer treated with radiotherapy

Frontiers in Oncology
Lung cancer is the leading cause of cancer-related death world-wide. Although the standard of care for patients with advanced stage lung cancer has significantly improved with the advent of immunotherapy and targeted agents, the overall prognosis remains
Shaowen Lyu, Rianne D. W. Vaes, Iris E. W. G. Laven, Francesco Cortiula, Francesco Cortiula, Lizza E. L. Hendriks, Marc A. Vooijs, Dirk K. M. De Ruysscher   +7 more
doaj   +1 more source