Results 41 to 50 of about 2,534,918 (292)

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics & Systems Pharmacology
Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for ...
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

A tutorial on physiologically based pharmacokinetic approaches in lactation research

CPT: Pharmacometrics & Systems Pharmacology
In breastfeeding mothers, managing medical conditions presents unique challenges, particularly concerning medication use and breastfeeding practices.
Amita Pansari, Xian Pan, Lisa M. Almond, Karen Rowland‐Yeo   +3 more
doaj   +1 more source

The physiological limits of bispecific monoclonal antibody tissue targeting specificity

mAbs
Bispecific monoclonal antibodies (bsmAbs) are expected to provide targeted drug delivery that overcomes the dose-limiting toxicities often accompanying antibody-drug conjugates (ADC) in clinical practice.
Armin Sepp, Felix Stader, Abdallah Derbalah, Cong Liu, Adriana Zyla, Iain Gardner, Masoud Jamei   +6 more
doaj   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

State-space approach to nonlinear predictive generalized minimum variance control [PDF]

, 2010
A Nonlinear Predictive Generalized Minimum Variance (NPGMV) control algorithm is introduced for the control of nonlinear discrete-time multivariable systems.
Majecki, P.M., Grimble, M.J., EPSRC on the Platform Grant Project No EP/C526422/1 (Funder)   +2 more
core   +4 more sources

Using the Simcyp R Package for PBPK Simulation Workflows With the Simcyp Simulator

CPT: Pharmacometrics & Systems Pharmacology
Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) modeling aims to understand how a drug is absorbed, distributed, metabolized, excreted, and acts in a human or animal body.
Anthonia M. Onasanwo, Naresh Mittapelly, Laura Shireman, Barry Vinden, Kevin McNally, James Craig, Frederic Y. Bois   +6 more
doaj   +1 more source

Understanding Pharmacokinetic-Drug Interactions With Drugs Approved by the US Food and Drug Administration in 2024 to Better Manage the Risk of Drug Interactions With Concomitant Medications: A Review of Clinical Data From New Drug Applications

Current Therapeutic Research
Objective: This analysis aimed to provide a mechanistic understanding and an evaluation of the clinical relevance of pharmacokinetic drug-drug interactions (DDIs) associated with drugs approved by the Food and Drug Administration in 2024.
Jingjing Yu, MD, PhD, Sophie Argon, PharmD, Katie Owens, BPharm, PhD, Yan Wang, MS, Isabelle Ragueneau-Majlessi, MD, MS   +4 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Adverse effects of diethyl phthalate and butyl benzyl phthalate on circadian rhythms and sleep patterns in zebrafish larvae

Ecotoxicology and Environmental Safety
The zebrafish, a diurnal vertebrate, is commonly used in circadian rhythm studies due to its genetic and neurological similarities to humans.
Soon Seok Kim, Sangwoo Lee, Kojo Eghan, Donggon Yoo, Hang-Suk Chun, Woo-Keun Kim   +5 more
doaj   +1 more source