Results 111 to 120 of about 2,049,122 (302)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Robust model predictive control with zone control

IET Control Theory & Applications, 2009
Model predictive control (MPC) is usually implemented as a control strategy where the system outputs are controlled within specified zones, instead of fixed set points. One strategy to implement the zone control is by means of the selection of different weights for the output error in the control cost function.
González, Alejandro Hernán, Marchetti, Jacinto Luis, Odloak, D.   +2 more
openaire   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Enhanced Model Predictive Control Using State Variable Feedback for Steady-State Error Cancellation

Sensors
The rapid dynamic responses of predictive control algorithms are widely acknowledged. However, achieving accurate steady-state reference tracking hinges not just on a precise mathematical model of the system but also on its parameters.
Marcos Andreu, Jaime Rohten, José Espinoza, José Silva, Esteban Pulido, Lesyani Leon   +5 more
doaj   +1 more source

Estimation and control using sampling-based Bayesian reinforcement learning

IET Cyber-Physical Systems, 2019
Real-world autonomous systems operate under uncertainty about both their pose and dynamics. Autonomous control systems must simultaneously perform estimation and control tasks to maintain robustness to changing dynamics or modelling errors.
Patrick Slade, Zachary N. Sunberg, Zachary N. Sunberg, Mykel J. Kochenderfer   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Extreme learning-based non-linear model predictive controller for an autonomous underwater vehicle: simulation and experimental results

IET Cyber-systems and Robotics, 2019
In this study, an extreme learning-based non-linear model predictive controller (NMPC) is proposed for path following planning of an autonomous underwater vehicle (AUV) using horizontal way-points. The proposed controller comprises a kinematic controller
Biranchi Narayan Rath, Bidyadhar Subudhi
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Contingency Model Predictive Control for Automated Vehicles

, 2019
We present Contingency Model Predictive Control (CMPC), a novel and implementable control framework which tracks a desired path while simultaneously maintaining a contingency plan -- an alternate trajectory to avert an identified potential emergency.
Alsterda, John P., Brown, Matthew, Gerdes, J. Christian   +2 more
core   +1 more source