Results 81 to 90 of about 127,481 (314)

Predictive modelling using pathway scores: robustness and significance of pathway collections

BMC Bioinformatics, 2019
Background Transcriptomic data is often used to build statistical models which are predictive of a given phenotype, such as disease status. Genes work together in pathways and it is widely thought that pathway representations will be more robust to noise
Marcelo P. Segura-Lepe, Hector C. Keun, Timothy M. D. Ebbels   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Emergent electrostatics in planar XY spin models: the bridge connecting topological order with broken U(1) symmetry

New Journal of Physics
Topological phases have been a central focus of condensed-matter physics for over 50 years. Along with many experimental applications, they have provided much intellectual interest due to their characterization via some form of topological ordering, as ...
Michael F Faulkner
doaj   +1 more source

Public health application of predictive modeling: an example from farm vehicle crashes

Injury Epidemiology, 2019
Background The goal of predictive modelling is to identify the likelihood of future events, such as the predictive modelling used in climate science to forecast weather patterns and significant weather occurrences.
Shabbar I. Ranapurwala, Joseph E. Cavanaugh, Tracy Young, Hongqian Wu, Corinne Peek-Asa, Marizen R. Ramirez   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Pattern analysis of schistosomiasis prevalence by exploring predictive modeling in Jiangling County, Hubei Province, P.R. China

Infectious Diseases of Poverty, 2017
Background The prevalence of schistosomiasis remains a key public health issue in China. Jiangling County in Hubei Province is a typical lake and marshland endemic area.
Shang Xia, Jing-Bo Xue, Xia Zhang, He-Hua Hu, Eniola Michael Abe, David Rollinson, Robert Bergquist, Yibiao Zhou, Shi-Zhu Li, Xiao-Nong Zhou   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Wiener modelling and model predictive control for wastewater applications

, 2005
The research presented in this paper aims to demonstrate the application of predictive control to an integrated wastewater system with the use of the wiener modeling approach.
Giovanini, L., O'Brien, M., Ordys, A.W., Katebi, M.R.   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Making space for an archaeology of place

, 2004
Rather than attempt to write a balanced or complete overview of the application of GIS to archaeology (which would inevitably end up being didactic and uncritical) this article sets out to present a discursive and contentious position with the deliberate
David Wheatley, Wheatley, David
core   +1 more source