Results 101 to 110 of about 743,383 (345)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure
Malaria JournalPlasmodium vivax malaria remains a global health challenge, with approximately 6.9 million estimated cases in 2022. The parasite has a dormant liver stage, the hypnozoite, which reactivates to cause repeated relapses over weeks, months, or years.
Nada Abla +17 more
doaj +1 more source
Frontiers in EndocrinologyObjectiveThis study aims to investigate the risk factors associated with contralateral occult carcinoma in patients with unilateral papillary thyroid carcinoma and to develop a corresponding prediction model to enhance early detection and clinical ...
ShiYi Zhao, Wei Yan, Jin Yu, DeJie Chen
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Geospatial HealthIntroduction: Chronic Obstructive Pulmonary Disease (COPD) mortality rates and global warming have been in the focus of scientists and policymakers in the past decade.
Alireza Mohammadi +4 more
doaj +1 more source
Topological Feature Based Classification [PDF]
, 2011 There has been a lot of interest in developing algorithms to extract clusters or communities from networks. This work proposes a method, based on blockmodelling, for leveraging communities and other topological features for use in a predictive ...
Peel, Leto
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The integration of artificial intelligence in assisted reproduction: a comprehensive review
Frontiers in Reproductive HealthArtificial Intelligence (AI) has emerged as a transformative force in healthcare, with its integration into assisted reproduction technologies representing a notable milestone.
Pragati Kakkar +6 more
doaj +1 more source
Capacity Management of Hyperscale Data Centers Using Predictive Modelling
Energies, 2019 Big Data applications have become increasingly popular with the emergence of cloud computing and the explosion of artificial intelligence. The increasing adoption of data-intensive machines and services is driving the need for more power to keep the data
Raihan Ul Islam +4 more
doaj +1 more source