Results 81 to 90 of about 883,483 (401)
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
PLoS ONE, 2019 Allergic rhinitis is a chronic inflammatory disease of the upper respiratory tract, which is associated with high incidence of anxiety symptom. There is evidence that medial prefrontal cortex modulates anxiety-related behaviors and receives projections ...
Morteza Salimi +8 more
doaj +1 more source
Cortical Dynamics of Contextually-Cued Attentive Visual Learning and Search: Spatial and Object Evidence Accumulation [PDF]
, 2009 How do humans use predictive contextual information to facilitate visual search? How are consistently paired scenic objects and positions learned and used to more efficiently guide search in familiar scenes?
Grossberg, Stephen, Huang, Tsung-Ren
core +4 more sources
Prefrontal cortex glutamate and extraversion [PDF]
Social Cognitive and Affective Neuroscience, 2011 Extraversion is considered one of the core traits of personality. Low extraversion has been associated with increased vulnerability to affective and anxiety disorders. Brain imaging studies have linked extraversion, approach behaviour and the production of positive emotional states to the dorsolateral prefrontal cortex (DLPFC) and glutamatergic ...
Maren Jaedke +4 more
openaire +3 more sources
Advanced Science, EarlyView.Pischiutta F and coworkers identify prostaglandins and kynurenine as key mediators of the mesenchymal stromal cells‐derived secretome's neuroprotective effects. A synthetic cocktail composed of these factors promotes long‐term functional recovery, reduces brain structural damage, and modulates neuroinflammation after traumatic brain injury, supporting ...
Francesca Pischiutta +24 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2016 Previous studies investigated the distinct roles played by different cognitive regions and suggested that the patterns of connectivity of these regions are associated with working memory.
Xiaojing eFang +11 more
doaj +1 more source
Competing neural responses for auditory and visual decisions. [PDF]
PLoS ONE, 2007 Why is it hard to divide attention between dissimilar activities, such as reading and listening to a conversation? We used functional magnetic resonance imaging (fMRI) to study interference between simple auditory and visual decisions, independently of ...
Grit Hein +3 more
doaj +1 more source
Frontiers in Human Neuroscience, 2021 Objective: We conducted this non-randomized prospective interventional study to clarify the relationship between improved attention-deficit hyperactivity disorder (ADHD) symptoms and regional brain activity.Methods: Thirty-one adult patients underwent ...
Atsunori Sugimoto +13 more
doaj +1 more source
The Prefrontal Cortex—An Update [PDF]
Neuron, 2001 I wish to thank Eric Kandel, James McGaugh, Earl Miller, and Thomas O'Dell for their comments on the manuscript.
openaire +3 more sources
Aging and the Spectral Properties of Brain Hemodynamics
Advanced Science, EarlyView.As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park +9 more
wiley +1 more source