Journal of Pharmacological Sciences, 2005 Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
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Conservation of Signaling Pathways of Xenobiotic-Sensing Orphan Nuclear Receptors, Chicken Xenobiotic Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor, from Birds to Humans [PDF]
, 2001 Christoph Handschin
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Regulation of bile acid receptor activity
Liver Research, 2018 Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 ...
Yu-Jui Yvonne Wan, Lili Sheng
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Chemical sensing by cell-surface chemoreceptor arrays: the roles of receptor cooperativity and adaptation [PDF]
arXiv, 2012 Most sensory cells use cross-membrane chemoreceptors to detect chemical signals in the environment. The biochemical properties and spatial organization of chemoreceptors play important roles in achieving and maintaining sensitivity and accuracy of chemical sensing.
arxiv
Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors [PDF]
, 2002 Linda B. Moore +7 more
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Effects of pharmaceuticals in fish: In vitro and in vivo studies [PDF]
, 2014 Fish may be exposed to an array of pharmaceuticals that are discharged into the aquatic environment, paralleling advances in medical knowledge, research and technology.
Corcoran, Jenna Frances
core
Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity [PDF]
, 2003 Grace L. Guo +7 more
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Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance [PDF]
, 2003 Isabelle Dussault +8 more
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Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
Journal of Lipid Research, 2002 The nuclear pregnane X receptor (PXR; NR1I2) is an integral component of the body's defense mechanism against chemical insult (chemoprotection). PXR is activated by a diverse array of lipophilic chemicals, including xenobiotics and endogenous substances,
Steven A. Kliewer, Timothy M. Willson
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