Cytoplasmic Localization of Pregnane X Receptor and Ligand-dependent Nuclear Translocation in Mouse Liver [PDF]
, 2004 E. James Squires +2 more
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Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia. [PDF]
Arch Toxicol, 2023 Itkonen A, Hakkola J, Rysä J.
europepmc +1 more source
Pregnane X Receptor SUMOylation and De-SUMOylation [PDF]
, 2014 The pregnane x receptor (PXR, NR1I2) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. PXR is activated by numerous lipophilic compounds, a variety of drugs and drug metabolites in clinical use.
Liu, Chang
core
Expression of Pregnane-X-Receptor Transcript in Peripheral Blood Mononuclear Cells and Correlation with Mdr1 Mrna [PDF]
, 2004 Andrew Owen +3 more
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Advances in drug resistance of triple negative breast cancer caused by pregnane X receptor. [PDF]
World J Clin Oncol, 2023 Rao ZZ, Tang ZW, Wen J.
europepmc +1 more source
Novel plant inducers of PXR-dependent cytochrome P450 3A4 expression in HepG2 cells
Saudi Pharmaceutical Journal, 2018 The cytochrome P450 3A4 (CYP3A4) is the most abundant CYP450 enzyme involved in the metabolism of endogenous products and xenobiotics, including prescription drugs and herbals.
Mohammed S. Al-Dosari +1 more
doaj
Protocatechuic acid inhibits LPS-induced mastitis in mice through activating the pregnane X receptor. [PDF]
J Cell Mol Med, 2023 Zhao L, Jin L, Yang B.
europepmc +1 more source
PXR-mediated Metabolism During Pregnancy and Cholestasis
, 2009 Nuclear receptors, including the pregnane x receptor (PXR) and the farnesoid x receptor (FXR), regulate the expression of genes that maintain bile acid (BA) homeostasis. Intrahepatic cholestasis of pregnancy (ICP) is a common gestational liver disease
Owen, Bryn Myers, Owen, Bryn Myers
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The Pregnane X Receptor Regulates Gene Expression in a Ligand- and Promoter- Selective Fashion [PDF]
, 2005 Hisashi Masuyama +5 more
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Perinatal Lipopolysaccharide Exposure Downregulates Pregnane X Receptor and Cyp3a11 Expression in Fetal Mouse Liver [PDF]
, 2005 De‐Xiang Xu +6 more
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