Results 181 to 190 of about 16,876 (211)
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Pregnane X Receptor: Promiscuous regulator of detoxification pathways
The International Journal of Biochemistry & Cell Biology, 2007The Pregnane X Receptor (PXR) is pivotal for the body's response to toxic xenobiotics and endogenous metabolites. By acting as a ligand-activated transcription factor, PXR regulates all stages of xenobiotic metabolism and transport and is responsible for important inductive drug interactions.
Marko, Matic +5 more
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[Advances on pregnane X receptor].
Sheng li ke xue jin zhan [Progress in physiology], 2012Pregnane X receptor (PXR), termed with its cognate ligand, is a member of the nuclear receptor superfamily. PXR is expressed mainly in liver, intestine, stomach and kidney, and plays a central role in protecting tissues from potentially toxic exogenous and endogenous compounds.
Dan, Pu, You-Fei, Guan
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A Pharmacophore for Human Pregnane X Receptor Ligands
Drug Metabolism and Disposition, 2002The pregnane X receptor (PXR) is involved in transcriptional regulation of multiple cytochromes P450 and multidrug resistance-associated protein (MDR1), which encodes for the drug transporter P-glycoprotein. Crystal structure analyses suggest that the ligand binding domain is highly hydrophobic and flexible, allowing molecules of differing sizes to ...
Sean, Ekins, Jon A, Erickson
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Epigenetic regulation of pregnane X receptor activity
Drug Metabolism Reviews, 2013Pregnane X receptor (PXR, NR1I2) is a ligand-dependent nuclear receptor (NR) that functions as a xenobiotic sensor and effector in coordinately regulating expression of genes of the xenobiotic detoxification network. PXR exerts its transcriptional regulatory functions by dimerization with retinoic X receptor RXR, and PXR-RXR complex binds to specific ...
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Rabbit Pregnane X Receptor Is Activated by Rifampicin
Drug Metabolism and Disposition, 2000Reverse transcriptase-polymerase chain reaction was used to amplify a partial cDNA from rabbit lung mRNA that shared 77% protein sequence identity with the mouse pregnane X receptor (PXR). Rapid amplification of cDNA ends from a rabbit kidney lambdaZAP expression library resulted in the isolation of overlapping cDNAs spanning the complete coding ...
U, Savas +3 more
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Ligand- and Structure-Based Pregnane X Receptor Models
2012The human pregnane X receptor (PXR) is a ligand dependent transcription factor that can be activated by structurally diverse agonists including steroid hormones, bile acids, herbal drugs, and prescription medications. PXR regulates the transcription of several genes involved in xenobiotic detoxification and apoptosis.
Sandhya, Kortagere +2 more
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Molecular Pharmacology, 2000
In this report we show that submicromolar concentrations of dexamethasone enhance pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human hepatocytes. Because this result is only observed after 24 h of cotreatment and is inhibited by pretreatment with cycloheximide, we further investigated which factor(s), induced by ...
J M, Pascussi +4 more
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In this report we show that submicromolar concentrations of dexamethasone enhance pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human hepatocytes. Because this result is only observed after 24 h of cotreatment and is inhibited by pretreatment with cycloheximide, we further investigated which factor(s), induced by ...
J M, Pascussi +4 more
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Pregnane X receptor: Predicting and preventing drug interactions
Thrombosis Research, 2005The pregnane X receptor, PXR, is a member of the nuclear receptor family of ligand-activated transcription factors [1]. The hormones that act through the nuclear receptors include the steroid hormones, thyroid hormone, retinoic acid, and vitamin D [2].
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Pregnane-X receptor/constitutive androsterone receptor
Toxicology Letters, 2008Patrick Balaguer +5 more
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