Results 11 to 20 of about 10,479 (197)
SPA70 is a potent antagonist of human pregnane X receptor [PDF]
Nature Communications, 2017 The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism. Here the authors develop hPXR modulators, which are of potential therapeutic interest and functionally and structurally characterize the antagonist SPA70 and the ...
Wenwei Lin +9 more
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Evolution of pharmacologic specificity in the pregnane X receptor [PDF]
BMC Evolutionary Biology, 2008 Background The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study, we determined the pharmacophores for activation of human, mouse, rat, rabbit, chicken,
Reschly Erica J +3 more
doaj +3 more sources
Pregnane X receptor and human malignancy [PDF]
Histology and histopathology, 2013 Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily, expressed in liver, intestine and other tissues. PXR exerts transcriptional regulation by binding to its DNA response elements as an heterodimer with Retinoid X Receptor (RXR).
Patsouris, Efstratios +2 more
core +6 more sources
Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia. [PDF]
Arch Toxicol, 2023 Pharmaceuticals and environmental contaminants contribute to hypercholesterolemia. Several chemicals known to cause hypercholesterolemia, activate pregnane X receptor (PXR).
Itkonen A, Hakkola J, Rysä J.
europepmc +2 more sources
Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor [PDF]
Frontiers in ImmunologyThe pregnane X receptor (PXR), a key hepatic nuclear receptor, exhibits a highly plastic ligand-binding domain (LBD) that recognizes diverse endogenous and exogenous ligands, contributing to interindividual variations in xenobiotic metabolism and toxic ...
Tong Lin +5 more
doaj +2 more sources
Post-translational Modification of Pregnane X Receptor [PDF]
Pharmacological Research, 2011 Pregnane x receptor (PXR, NR1I2) was originally characterized as a broad spectrum entero-hepatic xenobiotic ‘sensor’ and master-regulator of drug inducible gene expression.
Jeff L. Staudinger +7 more
core +4 more sources
The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells [PDF]
Frontiers in EndocrinologyIntroductionPregnane X Receptor (PXR, NR1I2) is a ligand-dependent transcription factor belonging to the nuclear receptor superfamily, that can be activated by a wide variety of endogenous and exogenous ligands.
Emmanuelle Martinot +4 more
doaj +2 more sources
Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor [PDF]
Molecular Medicine, 2023 Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect.
Shuang Wang +8 more
doaj +2 more sources
Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) [PDF]
Liver Research, 2022 Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associated
Anqi Cheng +6 more
doaj +2 more sources
PLoS ONE, 2014 Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X ...
PLOS ONE (2189197)
doaj +4 more sources