Recent advances in gut microbiota metabolite regulation of hepatic pregnane X receptor [PDF]
Frontiers in ImmunologyThe pregnane X receptor (PXR), a key hepatic nuclear receptor, exhibits a highly plastic ligand-binding domain (LBD) that recognizes diverse endogenous and exogenous ligands, contributing to interindividual variations in xenobiotic metabolism and toxic ...
Tong Lin +5 more
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Marine Ligands of the Pregnane X Receptor (PXR): An Overview [PDF]
Marine Drugs, 2019 Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the expression of a wide array of genes and is involved in cancer and different key physiological ...
Alejandro Carazo +2 more
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Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform [PDF]
Frontiers in PharmacologyPregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy ...
Caitlin Lynch +8 more
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The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells [PDF]
Frontiers in EndocrinologyIntroductionPregnane X Receptor (PXR, NR1I2) is a ligand-dependent transcription factor belonging to the nuclear receptor superfamily, that can be activated by a wide variety of endogenous and exogenous ligands.
Emmanuelle Martinot +4 more
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Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor [PDF]
Molecular Medicine, 2023 Background The morbidity and mortality of sepsis are extremely high, which is a major problem plaguing human health. However, current drugs and measures for the prevention and treatment of sepsis have little effect.
Shuang Wang +8 more
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Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) [PDF]
Liver Research, 2022 Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associated
Anqi Cheng +6 more
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Pregnane X receptor and drug-induced liver injury [PDF]
Expert Opinion on Drug Metabolism and Toxicology, 2014 The liver plays a central role in transforming and clearing foreign substances. The continuous exposure of the liver to xenobiotics sometimes leads to impaired liver function, referred to as drug-induced liver injury (DILI). The pregnane X receptor (PXR) tightly regulates the expression of genes in the hepatic drug-clearance system and its undesired ...
Taosheng Chen +2 more
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S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury [PDF]
JCI InsightDrug-induced liver injury (DILI), especially acetaminophen overdose, is the leading cause of acute liver failure. Pregnane X receptor (PXR) is a nuclear receptor and the master regulator of drug metabolism.
Qi Cui +13 more
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Cells, 2022 Plastic-associated endocrine disrupting chemicals (EDCs) have been implicated in the etiology of cardiovascular disease (CVD) in humans, but the underlying mechanisms remain elusive.
Jingwei Liu +5 more
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Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis [PDF]
Frontiers in ImmunologyBackgroundEpidemiological evidence suggests that particulate matter (PM) exposure can trigger or worsen atopic dermatitis (AD); however, the underlying mechanisms remain unclear. Recently, pregnane X receptor (PXR), a xenobiotic receptor, was reported to
Ji Su Lee +17 more
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