Results 31 to 40 of about 10,479 (197)

Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning

Cells, 2021
The pregnane X receptor (PXR, NR1I2) is a nuclear receptor which exerts its regulatory function by heterodimerization with the retinoid-X-receptor α (RXRα, NR2B1) and binding to the promoter and enhancer regions of diverse target genes.
Juan Pablo Rigalli, Dirk Theile, Julie Nilles, Johanna Weiss   +3 more
doaj   +1 more source

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Zevnik, Branko, Rode, Anja, Nicole Faust, Ross, Jillian, C. Roland Wolf, Nico Scheer, Scheer, Nico, Niehaves, Sandra, Sandra Niehaves, Faust, Nicole, Branko Zevnik, Wolf, C. Roland, Jillian Ross, Anja Rode   +13 more
core   +1 more source

Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism

Journal of Pharmacological Sciences, 2014
.: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
doaj   +1 more source

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]

, 2004
BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer, Handschin, C., Gnerre, C, Sharon Blättler, Meyer, U A, Blattler, S., Handschin, C, Podvinec, M, Oscarson, M., Michael Podvinec, Michel R Kaufmann, Adrian Roth, Kaufmann, M R, Looser, R, Carmela Gnerre, Roth, A., Roth, A, Meyer, U. A., Gnerre, C., Blättler, S, Christoph Handschin, Kaufmann, M. R., Renate Looser, Looser, R., Mikael Oscarson, Oscarson, M, Podvinec, M.   +26 more
core   +1 more source

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells [PDF]

, 2013
The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined.
Wei, Yijuan, Hu, Bingfang, Wen Xie, Xie Wen, Zhai Yonggong, Yonggong Zhai, Huang Min, Bingfang Hu, Hu, B, Xie, W, Jun Zhang, Yijuan Wei, Zhai, Yonggong, Xie, Wen, Min Huang, Zhang Jun, Hu Bingfang, Huang, M, Huang, Min, Wei Yijuan, Zhang, Jun, Zhang, J, Wei, Y, Zhai, Y   +23 more
core   +1 more source

Targeting the pregnane X receptor in liver injury [PDF]

Expert Opinion on Therapeutic Targets, 2012
The nuclear receptor pregnane X receptor (PXR) is a well-characterized hepatic xenobiotic sensor whose activation by chemically diverse compounds results in the induction of drug clearance pathways that rid the body of potentially toxic substances, thus conferring protection from foreign chemicals and endobiotics.PXR activities are implicated in drug ...
Tao, Li, Ruth T, Yu, Annette R, Atkins, Michael, Downes, Robert H, Tukey, Ronald M, Evans   +5 more
openaire   +2 more sources

Modulation of Xenobiotic Receptors by Steroids

Molecules, 2013
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins, Monimoy Banerjee, Taosheng Chen   +2 more
doaj   +1 more source

Role of pregnane X receptor in chemotherapeutic treatment [PDF]

Cancer Chemotherapy and Pharmacology, 2014
Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that differently expresses not only in human normal tissues but also in numerous types of human cancers. PXR can be activated by many endogenous substances and exogenous chemicals, and thus affects chemotherapeutic effects and intervenes drug-drug interactions by regulating its ...
Wei, Zhuo, Lei, Hu, Jinfeng, Lv, Hongbing, Wang, Honghao, Zhou, Lan, Fan   +5 more
openaire   +2 more sources

A Fresh Insight into the Interaction of Natural Products with Pregnane X Receptor

Natural Product Communications, 2008
The discovery that various drugs (e.g., phenobarbital) stimulate their own metabolism through a mechanism coined as enzymatic induction opened up a fascinating road that eventually led to the accurate biochemical characterization of the pregnane X ...
Salvador Máñez
doaj   +1 more source

Flame model Pregnane X receptor activation

, 2023
Dataset containing a Flame QSAR model for predicting Pregnane X receptor activation. The model is described in the metadata.txt file. The PXR_FAIR.tgz file can be imported into any instance of the open-source Flame (https://github.com/phi-grib/flame) and
Pastor, Manuel
core   +1 more source