Results 31 to 40 of about 8,905 (163)
Pregnane X receptor in drug-induced liver injury: Friend or foe?
Liver Research, 2018 The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
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Pregnane X receptor and human malignancy.
Histology and histopathology, 2013 Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily, expressed in liver, intestine and other tissues. PXR exerts transcriptional regulation by binding to its DNA response elements as an heterodimer with Retinoid X Receptor (RXR).
Koutsounas, Ioannis +2 more
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Modulation of Xenobiotic Receptors by Steroids
Molecules, 2013 Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic ...
Delira Robbins +2 more
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Targeting the pregnane X receptor in liver injury [PDF]
Expert Opinion on Therapeutic Targets, 2012 The nuclear receptor pregnane X receptor (PXR) is a well-characterized hepatic xenobiotic sensor whose activation by chemically diverse compounds results in the induction of drug clearance pathways that rid the body of potentially toxic substances, thus conferring protection from foreign chemicals and endobiotics.PXR activities are implicated in drug ...
Tao, Li +5 more
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A Fresh Insight into the Interaction of Natural Products with Pregnane X Receptor
Natural Product Communications, 2008 The discovery that various drugs (e.g., phenobarbital) stimulate their own metabolism through a mechanism coined as enzymatic induction opened up a fascinating road that eventually led to the accurate biochemical characterization of the pregnane X ...
Salvador Máñez
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Role of pregnane X receptor in chemotherapeutic treatment [PDF]
Cancer Chemotherapy and Pharmacology, 2014 Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that differently expresses not only in human normal tissues but also in numerous types of human cancers. PXR can be activated by many endogenous substances and exogenous chemicals, and thus affects chemotherapeutic effects and intervenes drug-drug interactions by regulating its ...
Wei, Zhuo +5 more
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Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis.
Kyle L. Flannigan +8 more
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Molecules, 2023 Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the ...
Claudia Finamore +11 more
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Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor
Journal of Pharmacological Sciences, 2014 .: The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is activated by a number of clinically prescribed drugs and herbal extracts.
Rongrong Deng +10 more
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Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity
Pharmacological ResearchMetabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie +4 more
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