Results 191 to 200 of about 235,181 (316)

Screening Method for the Identification of Compounds That Activate Pregnane X Receptor. [PDF]

Curr Protoc, 2022
Lynch C, Sakamuru S, Xia M.
europepmc   +1 more source

Promising assets of South Africa? Cyclopia genistoides and Hoodia gordonii [PDF]

, 2016
Previous pharmacological studies have shown that H. gordonii could have different mechanism of action than the already withdrawn sympathomimetic weight-loss medicines, thus a possibly better risk/benefit ratio than the former antiobesity drugs.
Roza Orsolya
core  

Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms [PDF]

, 2005
Carylyn J. Marek, Steven Tucker, Dimitrios Konstantinou, Lucy J. Elrick, Dee Haefner, Charalampos Sigalas, Graeme I. Murray, Bryan Goodwin, Matthew C. Wright   +8 more
openalex   +1 more source

Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations

Environment International
Pregnane X receptor (PXR) is a heterologous biosensor that is involved in the metabolic pathway of environmental pollutants, regulating the transcription of genes involved in biotransformation.
Ruige Wang, Yaqi Lin, Ying Sun, Bing Zhao, Lin Chen   +4 more
doaj  

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

Acta Pharmaceutica Sinica B, 2020
Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level.
Tomas Smutny, Jan Dusek, Lucie Hyrsova, Jana Nekvindova, Alzbeta Horvatova, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek   +7 more
doaj  

Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin [PDF]

, 2005
Jill Chrencik, Jillian Orans, Linda B. Moore, Yu Xue, Li Peng, Jon L. Collins, G. Bruce Wisely, Millard H. Lambert, Steven A. Kliewer, Matthew R. Redinbo   +9 more
openalex   +1 more source

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice. [PDF]

Mol Metab, 2023
Karpale M, Kummu O, Kärkkäinen O, Lehtonen M, Näpänkangas J, Herfurth UM, Braeuning A, Rysä J, Hakkola J.   +8 more
europepmc   +1 more source

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation. [PDF]

Acta Pharm Sin B, 2023
Florke Gee RR, Huber AD, Wu J, Bajpai R, Loughran AJ, Pruett-Miller SM, Chen T.   +6 more
europepmc   +1 more source

Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations [PDF]

arXiv
We present receptor hopping and receptor swapping free energy estimation protocols based on the Alchemical Transfer Method (ATM) to model the binding selectivity of a set of ligands to two arbitrary receptors. The receptor hopping protocol, where a ligand is alchemically transferred from one receptor to another in one simulation, directly yields the ...
arxiv  

A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway [PDF]

, 2006
Jie Zhou, Yonggong Zhai, Ying Mu, Haibiao Gong, Hirdesh Uppal, David Toma, Songrong Ren, Ronald M. Evans, Wen Xie   +8 more
openalex   +1 more source