Results 281 to 290 of about 235,181 (316)
Some of the next articles are maybe not open access.
Pregnane X receptor polymorphisms associated with human diseases
Expert Opinion on Therapeutic Targets, 2013Pregnane X receptor (PXR) belongs to the nuclear hormone receptor superfamily and is mostly expressed in liver and intestine. PXR is activated by a wide range of compounds, including drugs, and regulates the transcription of numerous metabolic enzymes implicated in cellular response to xenobiotics. Genetic variation in the PXR gene may influence a wide
Stamatios Theocharis +2 more
openaire +2 more sources
Pregnane X Receptor as the “Sensor and Effector” in Regulating Epigenome
Journal of Cellular Physiology, 2014The pregnane X receptor (PXR, NR1I2) is a ligand‐activated nuclear receptor which plays an essential role in organism's metabolic detoxification system by sensing the presence of xenobiotics and triggering detoxification responses. In addition to its role in xenobiotic metabolism, PXR has pleiotropic functions in regulating immune/inflammatory ...
Xi Ma, Yanan Tian, Jingshu Chen
openaire +3 more sources
Ligand- and Structure-Based Pregnane X Receptor Models
2012The human pregnane X receptor (PXR) is a ligand dependent transcription factor that can be activated by structurally diverse agonists including steroid hormones, bile acids, herbal drugs, and prescription medications. PXR regulates the transcription of several genes involved in xenobiotic detoxification and apoptosis.
Sean Ekins +3 more
openaire +3 more sources
Organic Letters, 2017
Alismanin A (1), a novel aromatic triterpenoid with a C34 skeleton, was isolated from Alisma orientale together with a rearranged nor-triterpenoid (2) and a 13,17-seco triterpenoid (3). Their structures were determined by a combination of HRESIMS, 2D NMR
Chao Wang +10 more
semanticscholar +1 more source
Alismanin A (1), a novel aromatic triterpenoid with a C34 skeleton, was isolated from Alisma orientale together with a rearranged nor-triterpenoid (2) and a 13,17-seco triterpenoid (3). Their structures were determined by a combination of HRESIMS, 2D NMR
Chao Wang +10 more
semanticscholar +1 more source
Pregnane X receptor: Predicting and preventing drug interactions
Thrombosis Research, 2005The pregnane X receptor, PXR, is a member of the nuclear receptor family of ligand-activated transcription factors [1]. The hormones that act through the nuclear receptors include the steroid hormones, thyroid hormone, retinoic acid, and vitamin D [2].
openaire +3 more sources
Pregnane X receptor expression in skin: the good and the bad
Experimental Dermatology, 2015Keywords: 7,12-dimethylbenz(a)anthracene; aryl hydrocarbon receptor; cancer; drug metabolism; pregane X ...
openaire +3 more sources
The impact of pregnane X receptor activation on liver fibrosis
Biochemical Society Transactions, 2006The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic uptake, metabolism and excretion.
openaire +4 more sources
Pregnane-X receptor/constitutive androsterone receptor
Toxicology Letters, 2008Vincent Cavaillès +5 more
openaire +2 more sources