Results 141 to 150 of about 15,454 (206)

TSPO Modulation by PIGA-1138 Attenuates Oxidative Stress and Preserves Retinal Function in Experimental Diabetic Retinopathy. [PDF]

Antioxidants (Basel)
Galante A, Corsi F, Amato R, Taliani S, Da Settimo F, Cammalleri M, Piano I, Dal Monte M, Gargini C.   +8 more
europepmc   +1 more source

Clinical and genetic spectrum of cytochrome P450 oxidoreductase deficiency in Chinese patients. [PDF]

Endocr Connect
Wang T, Li C, Han C, Zhao Y, Qi G, Qi G, Zheng L.   +6 more
europepmc   +1 more source

Characterization of Steroid Metabolic Pathways in Established Human and Mouse Cell Models. [PDF]

Int J Mol Sci
du Toit T, Groessl M, Pignatti E, Swart AC, Flück CE.   +4 more
europepmc   +1 more source

Whole-organism screening in a zebrafish model of CLN2 disease identifies pregnenolone as a modulator of lysosomal functions with anti-epileptic properties

Kiani LN, Civiletto G, Lizzo G, Zdebik A, Brickell G, Mahmood F, Nalkos DD, Michaelides L, Eldridge P, Young EM, McPherson H, Campanella M, Gut P, Russell C.   +13 more
europepmc   +1 more source

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Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze

Pharmacology Biochemistry and Behavior, 1994
The neurosteroids pregnenolone and pregnenolone sulfate were tested for anxiogenic/anxiolytic effects in mice on the elevated plus-maze. Pregnenolone in a dose of 0.01 micrograms/kg increased motor activity and caused an anxiogenic response, i.e., a decreased number of entries onto the open arms of the plus-maze.
R F Ritzmann, C L Melchior
exaly   +3 more sources

Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia [PDF]

Neuropsychopharmacology, 2009
The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus ameliorate hypothesized NMDA receptor hypofunction in schizophrenia ...
Richard S E Keefe, Patrizia Porcu, A Leslie Morrow   +2 more
exaly   +2 more sources

Metabolism of Pregnenolone and Pregnenolone Sulphate in Benign Essential Hypertension

Endocrine Research Communications, 1974
Patients with benign essential hypertension excreted in their urine less of the radioactive label associated with the injected tracer 3H-pregnenolone sulphate than control subjects, but more of the label associated with the 14C-pregnenolone tracer. In both groups, there was no difference in the urinary production rate of pregnenolone.
E L, Tan, W, Nowaczynski, O, Kuchel, J, Genest   +3 more
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The quantitative determination of pregnenolone and pregnenolone acetate by infrared spectrophotometry

Journal of the American Pharmaceutical Association (Scientific ed.), 1950
An infrared spectrophotometric method is described for the quantitative determination of pregnenolone and its acetate in pharmaceutical preparations. Optical density measurements are made at several intense absorption peaks, and the concentration is calculated independently from each measurement.
G, PAPINEAU-COUTURE, R A, BURLEY
openaire   +2 more sources