Results 151 to 160 of about 15,454 (206)
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Measurement of pregnenolone in blood
Steroids, 1970Abstract A radio-ligand assay for the measurement of pregnenolone in 5 ml of plasma has been devised. Pregnenolone is converted to progesterone enzymatically and measured as progesterone. The method has low blank value and high sensitivity (0.3 ng). Plasma concentrations of pregnenolone were (means ± SEM, ng/ml): men, 0.83 ± 0.08; women, follicular ...
J A, Bermudez, P, Doerr, M B, Lipsett
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Pregnenolone in Rheumatoid Arthritis
New England Journal of Medicine, 1951PREGNENOLONE (Δ 5-pregnen-3βol-20-one) has recently been recommended as effective in the treatment of rheumatoid arthritis.1 2 3 4 5 Since Cortisone (17 hydroxy-11 dehydrocorticosterone) and ACTH (adrenocorticotrophic hormone) are scarce, expensive and not free from side effects, interest in pregnenolone is growing.
J R, DORDICK +3 more
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1971
Publisher Summary Pregnenolone is the C21 steroid closest in structure to cholesterol, which is the most abundant sterol in the Eutheria. C21 steroid is by far the major precursor of all the steroid hormones in the adrenal gland, ovary, and testis.
S, Burstein, M, Gut
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Publisher Summary Pregnenolone is the C21 steroid closest in structure to cholesterol, which is the most abundant sterol in the Eutheria. C21 steroid is by far the major precursor of all the steroid hormones in the adrenal gland, ovary, and testis.
S, Burstein, M, Gut
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PLASMA PREGNENOLONE AND 17-OH-PREGNENOLONE IN HIRSUTE AMENORRHOEIC PATIENTS
Acta Endocrinologica, 1978ABSTRACT This study was designed (a) to examine the involvement of the Δ5-pregnenes, pregnenolone and 17-OH-pregnenolone in the abnormal steroidogenesis present in hirsute patients; and (b) to examine the possibility that suppressed adrenal 21-hydroxylase activity may frequently underlie the abnormal steroidogenesis in hirsute women.
D L, Lorber, T J, McKenna, D, Rabinowitz
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Pregnenolone production in pregnancy
American Journal of Obstetrics and Gynecology, 1971Abstract The blood metabolic clearance rate of pregnenolone was 2,950 L. per day at 11 to 12 weeks' gestation, 2,670 ± 389 (S.E.) L. per day between 33 and 36 weeks' gestation, and 4,250 ± 502 (S.E.) L. per day between 37 and 39 weeks' gestation. Thirty-three per cent of circulating pregnenolone was associated with the blood cells. In five subjects in
B, Little +6 more
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Radioimmunoassay of Plasma Pregnenolone
The Journal of Clinical Endocrinology & Metabolism, 1973ABSTRACT A radioimmunoassay for the measurement of plasma unconjugated pregnenolone (5Δ-P) is described. The 3-hemisuccinate of 5Δ-P was coupled to human serum albumin using carbodiimide. One adult ewe was immunized with 2 mg of this conjugate. The antiserum obtained after 7 months of immunization was used in the assay. One to two ml of plasma or serum,
G E, Abraham +4 more
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Journal of Endocrinology, 1973
SUMMARY In hypophysectomized rats, treatment with pregnenolone (pregn-5-en-3β-ol-20-one) for 14 days prevented testicular atrophy, maintained spermatogenesis but did not counteract Leydig cell atrophy. Spermatogenic activity was abolished when a 16α-nitrile group was attached to the pregnenolone molecule, but pregnenolone-16α ...
Y, Taché, H, Selye, S, Szabo, J, Taché
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SUMMARY In hypophysectomized rats, treatment with pregnenolone (pregn-5-en-3β-ol-20-one) for 14 days prevented testicular atrophy, maintained spermatogenesis but did not counteract Leydig cell atrophy. Spermatogenic activity was abolished when a 16α-nitrile group was attached to the pregnenolone molecule, but pregnenolone-16α ...
Y, Taché, H, Selye, S, Szabo, J, Taché
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PREGNENOLONE THERAPY IN UVEITIS
Archives of Ophthalmology, 1951THE DRAMATIC suppression of certain inflammatory reactions by cortisone and corticotropin (ACTH) is now well known. In the search for effective substitutes for these drugs, numerous other substances have been subjected to clinical trial by various investigators.
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Pregnenolone and Pregnenolone Sulfate Metabolismin Vivoand Uterine Extraction at Midgestation
The Journal of Clinical Endocrinology & Metabolism, 1974ABSTRACT The in vivo metabolism and uterine extraction of pregnenolone and pregnenolone sulfate have been studied during a continuous infusion of the radioactive steroids in 5 women at midgestation. The blood metabolic clearance rates of pregnenolone and pregnenolone sulfate were 3310 ± 435 (se) 1/day and 272 ± 27 (se) 1/day.
R B, Billiar +3 more
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The Journal of Clinical Endocrinology & Metabolism, 1976
Both pregnenolone and 17-OH-pregnenolone were found to be higher in the plasma of patients with poorly controlled congential adrenal hyperplasia than in normal subjects. The plasma levels of these precursor steroids were significantly correlated with urinary 17-ketosteroid and pregnanetriol excretion and with plasma testosterone. The mechanism where by
T J, McKenna +3 more
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Both pregnenolone and 17-OH-pregnenolone were found to be higher in the plasma of patients with poorly controlled congential adrenal hyperplasia than in normal subjects. The plasma levels of these precursor steroids were significantly correlated with urinary 17-ketosteroid and pregnanetriol excretion and with plasma testosterone. The mechanism where by
T J, McKenna +3 more
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