Effects of the Neurosteroid Pregnenolone Sulfate on Hippocampal Physiology
, 2013 Several recent studies have established a role for estrogens in ameliorating specific neurodegenerative disorders, mainly those associated with the cholinergic neurons of the basal forebrain and their targets in the cortex and hippocampus.
Steffensen, Dr. Scott, Jones, Marc
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Clinical and Translational ScienceOur aim was to evaluate biomarkers for organic anion transporting polypeptide 1B1 (OATP1B1) function using a hypothesis‐free metabolomics approach. We analyzed fasting plasma samples from 356 healthy volunteers using non‐targeted metabolite profiling by ...
Kreetta Hämäläinen +6 more
doaj +1 more source
Microbial aspects of anaerobic methane oxidation with sulfate as electron acceptor [PDF]
, 2009 Anaerobic oxidation of methane (AOM) is an important methane sink in the ocean but the microbes responsible for AOM are as yet resilient to cultivation.
Jagersma, C.G.
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The role of sulfate conjugates in the formation of adrenal steroids.
, 1968 Tritiated pregnenolone and pregnenolone sulfate were incubated with homogenates of normal human adrenal and adrenal tumor tissue. In a 30 min incubation with normal adrenal tissue, pregnenolone was shown to be converted to pregnenolone sulfate, 17-alpha ...
Killinger, Donald W.
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The metabolism of pregnenolone in normal subjects and hypertensive individuals.
, 1969 We have adapted the double isotope derivative assay technique for the measurement of the excretion rate of delta-5-pregnenediol, and applied this method for a comparative study of the metabolism of pregnenolone in normal subjects and hypertensive ...
Silah, Jack G.
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Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization. [PDF]
Neuropharmacology, 2019 Chisari M +9 more
europepmc +1 more source
Pregnenolone sulfate as a modulator of synaptic plasticity. [PDF]
Psychopharmacology (Berl), 2014 Smith CC, Gibbs TT, Farb DH.
europepmc +1 more source
Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants. [PDF]
Cell Mol Life SciKellner S, Berlin S.
europepmc +1 more source
A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. [PDF]
Mol Pharmacol, 2014 Smith CC +5 more
europepmc +1 more source
In vitro metabolism of pregnenolone to 7 alpha-hydroxypregnenolone by rainbow trout embryos
, 2014 Tissues taken from rainbow trout embryos at several developmental stages, were incubated in the presence of radioactively-labelled pregnenolone in order to determine the capability of salmonid embryos to metabolize steroids, such as pregnenolone, that ...
Leatherland, J. F. +6 more
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