Results 51 to 60 of about 449,800 (228)

Evolution of Minimally Invasive and Non-Invasive Preimplantation Genetic Testing: An Overview

Journal of Clinical Medicine
Preimplantation genetic testing (PGT) has become a common supplementary diagnοstic/testing tοol for in vitro fertilization (ΙVF) cycles due to a significant increase in cases of PGT fοr mοnogenic cοnditions (ΡGT-M) and de novο aneuplοidies (ΡGT-A) over ...
Efthalia Moustakli, Athanasios Zikopoulos, C. Skentou, I. Bouba, K. Dafopoulos, Ioannis Georgiou   +5 more
semanticscholar   +1 more source

India's first child using PGT-M, PGT-A and HLA matching for helping a sibling having β-thalassemia major

Journal of Human Reproductive Sciences, 2019
β-thalassemia is a common single-gene disorder in India, with hematopoietic stem cell transplantation (HSCT) being the only cure. HSCT with matched unrelated donor is less successful, whereas finding a human leukocyte antigen (HLA)-matched related donor ...
Jwal M Banker, Parul Arora, Rajni Khajuria, Manish Banker   +3 more
doaj   +1 more source

Hydroxychloroquine Associated with Lower Glomerular Filtration Rate Decline in Lupus Nephritis

Arthritis Care &Research, Accepted Article.
Background Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical. Therefore, we analyzed data from our
Shivani Garg, Brad Rovin, Brad C. Astor, Tripti Singh, Fauzia Hollnagel, Megan Kuik, Lexie Kolton, Callie Saric, S. Sam Lim, Christie M. Bartels   +9 more
wiley   +1 more source

The Different Biopsy Techniques

Fertility & Reproduction, 2023
Preimplantation genetic testing needs access to genomic DNA in order to execute a genetic test on a preimplantation embryo. Normally a few cells must be extracted or ‘biopsied’ from the embryo to achieve this.
Keshav Malhotra
doaj   +1 more source

Advancements and Applications of Preimplantation Genetic Testing in In Vitro Fertilization: A Comprehensive Review.

Cureus
Preimplantation genetic testing (PGT) has become an integral component of assisted reproductive technology (ART), offering couples the opportunity to screen embryos for genetic abnormalities before implantation during in vitro fertilization (IVF).
Sravya Gudapati, Kamlesh Chaudhari, D. Shrivastava, Seema Yelne   +3 more
semanticscholar   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

Preimplantation aneuploidy screening using embryonic cell-free DNA isolated from spent culture medium: a case report

Egyptian Journal of Medical Human Genetics
Background Chromosomal aberrations are frequent in human embryos and can be identified during IVF by performing preimplantation genetic testing for aneuploidies (PGT-A).
Lama Khudari, Marwan Halabi, Sahar Al Fahoum   +2 more
doaj   +1 more source

Preimplantation genetic testing for aneuploidy optimizes reproductive outcomes in recurrent reproductive failure: a systematic review

Frontiers in Medicine
Introduction Recurrent reproductive failure (RRF) is a common pregnancy complication, imposing great physical, emotional and financial burden for the suffered couples.
Youwen Mei, Yonghong Lin, Ying Chen, Jiafeng Zheng, Xue Ke, Xuefei Liang, Fang Wang   +6 more
semanticscholar   +1 more source

Single‐Cell Nucleus Extraction with Cellular Indexing

Advanced Science, EarlyView.
VacTrap is a multilayer, high‐throughput microfluidic system that isolates and spatially indexes single nuclei from hundreds of cells within minutes. Using dissolvable hydrogel trapdoors triggered by chemical and vacuum actuation, VacTrap synchronously transfers nuclei while preserving spatial links to parent cells.
Trinh Lam, Ana Esmeralda Gomez Martinez, Alison Su, Anna Fomitcheva‐Khartchenko, Xin Wang, Md Nazibul Islam, Paul Lum, Amy Elizabeth Herr   +7 more
wiley   +1 more source

Preimplantation Genetic Testing of Multiple Endocrine Neoplasia Type 2A

Frontiers in Endocrinology, 2020
Background: When discussing matters of reproduction, the 2015 revised guidelines for the management of medullary thyroid carcinoma recommend that patients diagnosed with multiple endocrine neoplasia type 2A (MEN 2A) are informed about the option of ...
Anders Würgler Hansen, Anders Würgler Hansen, Laura Kirstine Sønderberg Roos, Kristine Løssl, Christian Godballe, Christian Godballe, Jes Sloth Mathiesen, Jes Sloth Mathiesen   +7 more
doaj   +1 more source