Results 51 to 60 of about 24,363 (274)

Challenges experienced by genetic counselors while they provided counseling about mosaic embryos

F&S Reports, 2023
Objective: To survey genetic counselors (GCs) who have counseled about mosaic embryos regarding the challenges they faced in counseling this patient population and assess their need for more resources to support their practice.
Olivia M. Moran, M.Sc., Kayla Flamenbaum, M.S., Diane Myles Reid, M.S., Jeanna M. McCuaig, Ph.D., Riyana Babul-Hirji, M.Sc., David Chitayat, M.D., Maian Roifman, M.D.   +6 more
doaj   +1 more source

The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues [PDF]

, 2006
The interface between assisted reproductive technologies (ART) and genetics comprises several sensitive and important issues that affect infertile couples, families with severe genetic diseases, potential children, professionals in ART and genetics ...
ANASTASIADOU V, AYMÉ S, BRAGA S, CORNEL M, COVIELLO, DOMENICO, ESHG, ESHRE, EVERS KIEBOOMS G, GERAEDTS J, GIANAROLI L, HARPER J, IBARRETA D, KÄÄRIÄINEN H, KOSZTOLANYI G, LUNDIN K, RODRIGUES CEREZO E, SEQUEIROS J, SERMON K, SOINI S, TRANEBJAERG L   +18 more
core   +1 more source

Potential of preimplantation genomic selection using the blastomere separation technique in bovine in vitro fertilized embryos

The Journal of Reproduction and Development, 2021
Preimplantation genomic selection combined with an in vitro embryo production system is expected as a means of accelerating genetic improvement in cattle.
Takashi FUJII, Akira NAITO, Satoru MORIYASU, Soichi KAGEYAMA   +3 more
doaj   +1 more source

Ovarian stimulation for preimplantation genetic testing [PDF]

Reproduction, 2019
A narrative review of the management of controlled ovarian stimulation in patients undergoing preimplantation genetic testing is presented. An electronic search was performed to identify research publications that addressed ovarian stimulation and preimplantation genetic testing published until December 2017.
Jorge, Rodriguez-Purata, Francisca, Martinez   +1 more
openaire   +2 more sources

Provision and Quality Assurance of Preimplantation Genetic Diagnosis in Europe [PDF]

, 2008
Preimplantation genetic diagnosis (PGD) is now well established and provided in many European countries. However, regulations, professional standards and accreditation requirements can differ notably.
IBARRETA RUIZ DOLORES, ZIKA Eleni
core   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

India's first child using PGT-M, PGT-A and HLA matching for helping a sibling having β-thalassemia major

Journal of Human Reproductive Sciences, 2019
β-thalassemia is a common single-gene disorder in India, with hematopoietic stem cell transplantation (HSCT) being the only cure. HSCT with matched unrelated donor is less successful, whereas finding a human leukocyte antigen (HLA)-matched related donor ...
Jwal M Banker, Parul Arora, Rajni Khajuria, Manish Banker   +3 more
doaj   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

Preimplantation aneuploidy screening using embryonic cell-free DNA isolated from spent culture medium: a case report

Egyptian Journal of Medical Human Genetics
Background Chromosomal aberrations are frequent in human embryos and can be identified during IVF by performing preimplantation genetic testing for aneuploidies (PGT-A).
Lama Khudari, Marwan Halabi, Sahar Al Fahoum   +2 more
doaj   +1 more source

Genetic Normalization of Differentiating Aneuploid Human Embryos [PDF]

, 2011
Early embryogenesis involves a series of dynamic processes, many of which are currently not well described or understood. Aneuploidy and aneuploid mosaicism, a mixture of aneuploid and euploid cells within one embryo, in early embryonic development are ...
Andrew Barker, Andrew Benner, Garry Cutting, Kevin Richter, Khanh-Ha Nguyen, Paul Brezina, Raymond Anchan, Ric Ross, William Kearns   +8 more
core   +1 more source