Results 31 to 40 of about 847 (152)

Prêt-à-Porter Procreation: Contemplating the Ban on Preimplantation Sex Selection

Potchefstroom Electronic Law Journal, 2019
Preimplantation genetic testing makes it possible to genetically test in vitro embryos for the presence of genetic disease. It also identifies the sex of the embryo.
Sheetal Soni
doaj   +1 more source

Preimplantation Genetic Testing: Indications and Controversies [PDF]

Clinics in Laboratory Medicine, 2010
In the last two decades, the use of preimplantation genetic testing has increased dramatically. This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic ...
Amber R, Cooper, Emily S, Jungheim
openaire   +2 more sources

Challenges experienced by genetic counselors while they provided counseling about mosaic embryos

F&S Reports, 2023
Objective: To survey genetic counselors (GCs) who have counseled about mosaic embryos regarding the challenges they faced in counseling this patient population and assess their need for more resources to support their practice.
Olivia M. Moran, M.Sc., Kayla Flamenbaum, M.S., Diane Myles Reid, M.S., Jeanna M. McCuaig, Ph.D., Riyana Babul-Hirji, M.Sc., David Chitayat, M.D., Maian Roifman, M.D.   +6 more
doaj   +1 more source

Application of microdeletion and microduplication screening in preimplantation genetic testing: a case report

Journal of Medical Case Reports
Background Microdeletions and microduplications are chromosomal variants ranging up to 3 Mb in size. These abnormalities often arise spontaneously and have significant clinical implications, including developmental delay and congenital anomalies.
Maria Katz, Ben Podgursky, Shenglai Li, Qinnan Zhang, Daniel Shapiro, Monica Pasternak, Noor Siddiqui, Funda Suer, Yuntao Xia   +8 more
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Potential of preimplantation genomic selection using the blastomere separation technique in bovine in vitro fertilized embryos

The Journal of Reproduction and Development, 2021
Preimplantation genomic selection combined with an in vitro embryo production system is expected as a means of accelerating genetic improvement in cattle.
Takashi FUJII, Akira NAITO, Satoru MORIYASU, Soichi KAGEYAMA   +3 more
doaj   +1 more source

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

AI‐Driven Mapping of Seizure Spread Patterns

Annals of Neurology, EarlyView.
Objective The focus of epilepsy research has largely been on seizure onset; however, physicians typically examine the patterns of seizure spread past seizure onset as well. This study aims to align automated seizure analysis with clinical practice, leverage deep learning to standardize seizure annotations that varies among physicians, and understand ...
Andrew Y. Revell, Marc Jaskir, Akash R. Pattnaik, William K. S. Ojemann, Erin Conrad, Nishant Sinha, Brittany H. Scheid, Alfredo Lucas, John M. Bernabei, John Beckerle, Joel M. Stein, Sandhitsu R. Das, Brian Litt, Kathryn A. Davis   +13 more
wiley   +1 more source

Preimplantation aneuploidy screening using embryonic cell-free DNA isolated from spent culture medium: a case report

Egyptian Journal of Medical Human Genetics
Background Chromosomal aberrations are frequent in human embryos and can be identified during IVF by performing preimplantation genetic testing for aneuploidies (PGT-A).
Lama Khudari, Marwan Halabi, Sahar Al Fahoum   +2 more
doaj   +1 more source

India's first child using PGT-M, PGT-A and HLA matching for helping a sibling having β-thalassemia major

Journal of Human Reproductive Sciences, 2019
β-thalassemia is a common single-gene disorder in India, with hematopoietic stem cell transplantation (HSCT) being the only cure. HSCT with matched unrelated donor is less successful, whereas finding a human leukocyte antigen (HLA)-matched related donor ...
Jwal M Banker, Parul Arora, Rajni Khajuria, Manish Banker   +3 more
doaj   +1 more source