Correction to "Preimplantation Genetic Testing for Aneuploidy and Chromosomal Structural Rearrangement: A Summary of a Nationwide Study by the Japan Society of Obstetrics and Gynecology". [PDF]
Reprod Med Bioleuropepmc +1 more source
Preimplantation Genetic Testing for Aneuploidy – A Castle Built on Sand [PDF]
Trends in Molecular Medicine, 2021 Preimplantation genetic testing for aneuploidy (PGT-A) has become a routine add-on for in vitro fertilization (IVF) to determine whether human embryos are to be clinically utilized or disposed of. Studies claiming IVF outcome improvements following PGT-A, however, used highly selected patient populations or inappropriate statistical methodologies.
Norbert Gleicher +2 more
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Live Birth With or Without Preimplantation Genetic Testing for Aneuploidy
New England Journal of Medicine, 2021(Abstracted from N Engl J Med 2021;385:2047–2058) To optimize live birth rate per transfer in in vitro fertilization (IVF), morphologic score based on visualization and genetic status based on preimplantation genetic testing for aneuploidy (PGT-A) are used to select the highest quality embryos.
Xiaoxi Sun, Zi-Jiang Chen, Xiufeng Ling
exaly +3 more sources
A Systematic Review on Concurrent Aneuploidy Screening and Preimplantation Genetic Testing for Hereditary Disorders: What Is the Prevalence of Aneuploidy and Is There a Clinical Effect From Aneuploidy Screening? [PDF]
Acta Obstetricia Et Gynecologica Scandinavica, 2020 INTRODUCTION: In assisted reproductive technology, aneuploidy is considered a primary cause of failed embryo implantation. This has led to the implementation of preimplantation genetic testing for aneuploidy in some clinics.
Anja Ernst, Henrik Okkels, Birte Degn
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Preimplantation Genetic Testing for Aneuploidy: Current Perspectives
Seminars in Reproductive Medicine, 2021AbstractDespite improvements in assisted reproduction techniques (ARTs), live birth rates remain suboptimal, particularly in women with advanced maternal age (AMA). The leading cause of poor reproductive outcomes demonstrated in women with AMA, as well as women with recurrent miscarriage and repetitive implantation failure, is thought to be due to high
Ariadne L'Heveder +4 more
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Preimplantation Genetic Testing for Aneuploidy
Obstetrics & Gynecology, 2021Preimplantation genetic testing for aneuploidy was developed as an invasive embryo-selection technique and is extensively used in in vitro fertilization (IVF) cycles. Around 95,000 preimplantation genetic testing cycles were carried out in the United States between 2014 and 2016, the majority of which were performed for aneuploidy.
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Conventional IVF is feasible in preimplantation genetic testing for aneuploidy
Journal of Assisted Reproduction and Genetics, 2023To investigate the feasibility of the application of conventional in vitro fertilization (cIVF) for couples undergoing preimplantation genetic testing for aneuploidies (PGT-A) with non-male factor infertility.To evaluate the efficiency of sperm whole-genome amplification (WGA), spermatozoa were subjected to three WGA protocols: Picoplex, ChromInst, and
Shuoping Zhang +12 more
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Preimplantation Genetic Testing for Aneuploidy: A Review
Obstetrical & Gynecological Survey, 2019Importance Preimplantation genetic testing for aneuploidy (PGT-A) has undergone many technical developments over recent years, including changes in biopsy timings, methodology, and genetic analysis techniques.
James M, Kemper +2 more
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Journal of Visualized Experiments, 2019Chromosomal aneuploidy, one of the main causes leading to embryonic development arrest, implantation failure, or pregnancy loss, has been well documented in human embryos. Preimplantation genetic testing for aneuploidy (PGT-A) is a genetic test that significantly improves reproductive outcomes by detecting chromosomal abnormalities of embryos.
Baoheng, Gui +9 more
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The impact of preimplantation genetic testing for aneuploidy on prenatal screening
Journal of Perinatal Medicine, 2021Abstract Objectives To determine whether preimplantation genetic testing for aneuploidy (PGT-A) is associated with a reduced risk of abnormal conventional prenatal screening results in singleton pregnancies conceived using in vitro fertilization (IVF).
Moti Gulersen +9 more
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