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Hereditary angioedema (HAE) in children and adolescents: New treatment options. [PDF]

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Fasshauer M, Wedi B.
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Congenital prekallikrein deficiency

Expert Review of Hematology, 2010
The congenital deficiency of prekallikrein (PK) is a rare condition in which there is a peculiar discrepancy between a severe in vitro defect and absence of bleeding. The gene controlling PK synthesis is located on chromosome 4 and consists of 14 exons and 15 introns.
Antonio Girolami, Pamela Scarparo, Anna Maria Lombardi   +2 more
exaly   +3 more sources

Kinetics of activation of prekallikrein by prekallikrein activator

Biochemistry, 1980
A 28 000 molecular weight activator of prekallikrein was isolated from human plasma, and the kinetics of its enzymic activity toward prekallikrein was investigated. The activation follows Michaelis-Menten kinetics with a kcat of approximately 3 S(-1); Km is strongly dependent upon the ionic strength. Under suitable conditions the activation obeys first-
D L, Tankersley, M A, Fournel, D D, Schroeder   +2 more
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Inhibition of Prekallikrein for Hereditary Angioedema

New England Journal of Medicine, 2022
Hereditary angioedema is characterized by recurrent and unpredictable swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein production by antisense oligonucleotide treatment (donidalorsen) may reduce the frequency of attacks and the burden of disease.In this phase 2 trial, we randomly assigned, in a 2:1 ratio,
Lauré M. Fijen, Marc A. Riedl, Laura Bordone, Jonathan A. Bernstein, Jason Raasch, Raffi Tachdjian, Timothy Craig, William R. Lumry, Michael E. Manning, Veronica J. Alexander, Kenneth B. Newman, Alexey Revenko, Brenda F. Baker, Charvi Nanavati, A. Robert MacLeod, Eugene Schneider, Danny M. Cohn   +16 more
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Prekallikrein deficiency in a dog

Journal of the American Veterinary Medical Association, 1986
A 15-year-old male dog with chronic hematuria was found to have prolonged activated partial thromboplastin time. Results of plasma coagulation assays indicated a deficiency of prekallikrein, a plasma protein that modulates the rate of activation of factors XI and XII in the intrinsic clotting system.
D R, Chinn, W J, Dodds, B A, Selcer
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Dextran‐Induced Lowering of Prekallikrein Proactivator and Prekallikrein in Rat Plasma

Acta Pharmacologica et Toxicologica, 1978
Abstract The intravenous injection into rats of dextran (average M W 70,000) 10 mg/100 g caused marked hypotension after a delay of about 5 minutes. Blood samples collected by cardiac puncture at this time were tested for the amounts of prekallikrein activator (PKA) and kallikrein after acetone‐ and then kaolin activation of the plasminogen‐free plasma.
G, Briseid, K, Briseid, E L, Toverud, J, Kristoffersen   +3 more
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Prekallikrein Deficiency

Journal of Pediatric Oncology Nursing, 2013
Nurses often encounter abnormal laboratory assays that require them to investigate further to ensure that appropriate patient care is provided. A prolonged activated partial thromboplastin time (PTT) with a normal prothrombin time (PT) assay demand further examination, to rule out laboratory error or bleeding disorders.
openaire   +2 more sources

Simple Assay for Prekallikrein Activators

Immunological Communications, 1973
A simple assay has been devised for the measurement of the activity of the activators of prekallikrein. This method measures the arginine esterase activity of kallikrein, after release by the action of an activator on prekallikrein. Activator samples are incubated with the substrate (normal plasma) for exactly 60 seconds at 25°C and esterase activity ...
A, Bagdasarian, R C, Talamo, R W, Colman
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