Results 71 to 80 of about 4,917 (213)
Медицинский вестник Юга России, 2018 Objective: determination of levels of the kallikrein-kinin system (KKS) indicators in cutaneous melanoma and in the skin not associated with tumor in female mice with chronic neurogenic pain in the dynamics of В16/F10 melanoma growth.
O. I. Kit +8 more
doaj +1 more source
The distribution of lectins across the phylum Nematoda : a genome-wide search [PDF]
, 2017 Nematodes are a very diverse phylum that has adapted to nearly every ecosystem. They have developed specialized lifestyles, dividing the phylum into free-living, animal, and plant parasitic species. Their sheer abundance in numbers and presence in nearly
Bauters, Lander +2 more
core +3 more sources
The Challenges of Vascular Implants: Regulatory Strategies and Biological Responses
Small Science, Volume 5, Issue 12, December 2025.Implantable vascular devices are revolutionizing the management of cardiovascular diseases, such as heart failure, by enabling real‐time monitoring and individualized therapy. However, their potential is challenged by regulatory constraints and biological barriers, as device implantation into a vessel can trigger inflammation, thrombosis, and long‐term
Serena Babboni +5 more
wiley +1 more source
Protease: Serpin complexes to assess contact system and intrinsic pathway activation
Research and Practice in Thrombosis and Haemostasis, 2020 Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation of factor XII,
Michael W. Henderson +6 more
doaj +1 more source
Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs [PDF]
, 2017 Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant management in venous thrombosis. While efficacious, they are difficult to use due to interpatient dose–response variability and the risks of bleeding.
Banner D. W. +9 more
core +2 more sources
Status quo and future developments in the diagnosis and treatment of hereditary angioedema
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 12, Page 1512-1525, December 2025.Summary Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life‐threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is characterized by a deficiency (type I) or loss of function (type II) of the C1 inhibitor (C1‐INH), leading to excessive ...
Andreas Recke
wiley +1 more source
A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain [PDF]
, 2016 Factor XI (FXI) is the zymogen of FXIa, which cleaves FIX in the intrinsic pathway of coagulation. FXI is known to exist as a dimer and interacts with multiple proteins via its 4 apple domains in the “saucer section” of the enzyme; however, to date, no ...
Baba +49 more
core +2 more sources
Protease activity in single-chain prekallikrein
Blood, 2020 AbstractPrekallikrein (PK) is the precursor of the trypsin-like plasma protease kallikrein (PKa), which cleaves kininogens to release bradykinin and converts the protease precursor factor XII (FXII) to the enzyme FXIIa. PK and FXII undergo reciprocal conversion to their active forms (PKa and FXIIa) by a process that is accelerated by a variety of ...
David Gailani +9 more
openaire +3 more sources
European Journal of Inorganic Chemistry, Volume 28, Issue 26, September 24, 2025.Calcium silicate materials are synthesized using eggshell waste as a sustainable calcium source. Quaternary ammonium salts are employed as key structure‐directing agents, favoring the formation of the clay‐like mineral rhodesite with a significantly higher surface area than previously reported. The hemostatic performance of the synthesized materials is
Guilherme de Paula Guarnieri +8 more
wiley +1 more source
High quality human immunoglobulin G purified from Cohn fractions by liquid chromatography
Brazilian Journal of Medical and Biological Research, 2000 In order to obtain intravenous immunoglobulin G (iv IgG) of high quality from F-I+II+III or F-II+III pastes prepared by the Cohn method, we developed a chromatography process using ion exchange gels, Q-Sepharose FF and CM-Sepharose FF, and Sephacryl S ...
K. Tanaka +6 more
doaj +1 more source