Results 61 to 70 of about 16,266,038 (328)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees +6 morewiley +1 more sourceDual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix +13 morewiley +1 more sourceThe Pierre Auger Observatory Upgrade - Preliminary Design Report [PDF]
, 2016 The Pierre Auger Observatory has begun a major Upgrade of its already impressive capabilities, with an emphasis on improved mass composition determination using the surface detectors of the Observatory. Known as AugerPrime, the upgrade will include new 4 T. P. A. C. A. Aab, P. Abreu, M. Aglietta, E. Ahn, I. A. Samarai, I. Albuquerque, I. Allekotte, P. Allison, A. Almela, J. A. Castillo, J. Álvarez-Muñiz, R. A. Batista, M. Ambrosio, A. Aminaei, L. Anchordoqui, S. Andringa, C. Aramo, F. Arqueros, N. Arsene, Hernán Asorey, P. Assis, J. Aublin, M. Ave, M. Avenier, G. Avila, N. Awal, A. Badescu, K. B. Barber, J. Bauml, C. Baus, J. Beatty, K. Becker, J. Bellido, C. Bérat, M. Bertaina, X. Bertou, P. Biermann, P. Billoir, S. Blaess, A. Blanco, M. Blanco, J. Blažek, C. Bleve, H. Blumer, M. Boh'avcov'a, D. Boncioli, C. Bonifazi, N. Borodai, J. Brack, I. Brancus, A. Bridgeman, P. Brogueira, W. C. Brown, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K. Caballero-Mora, B. Caccianiga, L. Caccianiga, M. Candusso, L. Caramete, R. Caruso, A. Castellina, G. Cataldi, L. Cazon, R. Cester, A. Chavez, A. Chiavassa, J. Chinellato, J. Chudoba, M. Cilmo, R. Clay, G. Cocciolo, R. Colalillo, A. Coleman, L. Collica, M. Coluccia, R. Conceiccao, F. Contreras, M. Cooper, A. Cordier, S. Coutu, C. Covault, J. Cronin, R. Dallier, B. Daniel, S. Dasso, K. Daumiller, B. Dawson, R. M. Almeida, S. Jong, G. D. Mauro, J. D. M. Neto, I. Mitri, J. D. Oliveira, V. Souza, L. Peral, O. Deligny, H. Dembinski, N. Dhital, C. D. Giulio, A. Matteo, J. Diaz, M. L. D. Castro, F. Diogo, C. Dobrigkeit, W. Docters, J. D'Olivo, A. Dorofeev, Q. Hasankiadeh, M. Dova, J. Ebr, R. Engel, M. Erdmann, M. Erfani, C. Escobar, J. Espadanal, A. Etchegoyen, H. Falcke, K. Fang, G. Farrar, A. Fauth, N. Fazzini, A. Ferguson, M. Fernandes, B. Fick, J. M. Figueira, A. Filevich, A. Filipvcivc, B. Fox, O. Fratu, M. Freire, B. Fuchs, T. Fujii, B. Garc'ia, D. García-Pinto, F. Gaté, H. Gemmeke, A. Gherghel-Lascu, P. Ghia, U. Giaccari, M. Giammarchi, M. Giller, D. Glas, C. Glaser, H. Glass, G. Golup, M. G. Berisso, P. Vitale, N. Gonz'alez, B. Gookin, J. Gordon, A. Gorgi, P. Gorham, P. Gouffon, N. Griffith, A. Grillo, T. D. Grubb, F. Guarino, G. Guedes, M. Hampel, P. Hansen, D. Harari, T. Harrison, S. Hartmann, J. Harton, A. Haungs, T. Hebbeker, D. Heck, P. Heimann, N. Hemery, A. Hervé, G. Hill, C. Hojvat, N. Hollon, E. Holt, P. Homola, J. Horandel, P. Horváth, M. Hrabovsk'y, D. Huber, T. Huege, A. Insolia, P. G. Isar, I. Jandt, S. Jansen, C. Jarne, J. Johnsen, M. Josebachuili, A. Kaapa, O. Kambeitz, K. Kampert, P. Kasper, I. Katkov, B. K'egl, B. Keilhauer, A. Keivani, E. Kemp, R. Kieckhafer, H. Klages, M. Kleifges, J. Kleinfeller, R. Krause, N. Krohm, O. Kromer, D. Kuempel, G. K. Mezek, N. Kunka, D. LaHurd, L. Latronico, R. Lauer, M. Lauscher, P. Lautridou, S. L. Coz, D. Lebrun, P. Lebrun, M. Oliveira, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, L. Lopes, R. L'opez, A. L. Casado, K. Louedec, L. Lu, A. Lucero, M. Malacari, S. Maldera, M. Mallamaci, J. Maller, D. Mandát, P. Mantsch, A. Mariazzi, V. Marin, I. Marics, G. Marsella, D. Martello, L. Martin, H. Martinez, O. M. Bravo, D. Martraire, J. Meza, H. Mathes, S. Mathys, J. Matthews, J. Matthews, G. Matthiae, D. Maurizio, E. Mayotte, P. Mazur, C. Medina, G. Medina-Tanco, R. Meißner, V. Mello, D. Melo, A. Menshikov, S. Messina, R. Meyhandan, M. Micheletti, L. Middendorf, I. Minaya, L. Miramonti, B. Mitrica, L. Molina-Bueno, S. Mollerach, F. Montanet, C. Morello, M. Mostaf'a, C. Moura, M. Muller, G. Muller, S. Muller, R. Mussa, G. Navarra, S. Navas, P. Nečesal, L. Nellen, A. Nelles, J. Neuser, P. Nguyen, M. Niculescu-Oglinzanu, M. Niechciol, L. Niemietz, T. Niggemann, D. Nitz, D. Nosek, V. Novotny, L. Novzka, L. Ochilo, F. Oikonomou, A. Olinto, N. Pacheco, D. P. Selmi-Dei, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, T. Paul, M. Pech, J. Pcekala, R. Pelayo, I. Pepe, L. Perrone, E. Petermann, C. Peters, S. Petrera, Y. Petrov, J. Phuntsok, R. Piegaia, T. Pierog, P. Pieroni, M. Pimenta, V. Pirronello, M. Platino, M. Plum, A. Porcelli, C. Porowski, R. Prado, P. Privitera, M. Prouza, V. Purrello, E. Quel, S. Querchfeld, S. Quinn, J. Rautenberg, O. Ravel, D. Ravignani, D. Reinert, B. Revenu, J. Řídký, S. Riggi, M. Risse, P. Ristori, V. Rizi, W. Carvalho, G. Fernandez, J. Rojo, M. D. Rodr'iguez-Fr'ias, D. Rogozin, J. Rosado, M. Roth, E. Roulet, A. Rovero, S. Saffi, A. Săftoiu, F. Salamida, H. Salazar, A. Saleh, F. Greus, G. Salina, F. S'anchez, P. Sanchez-Lucas, E. Santos, E. Santos, F. Sarazin, B. Sarkar, R. Sarmento, R. Sato, C. Scarso, M. Schauer, V. Scherini, H. Schieler, D. Schmidt, O. Scholten, H. Schoorlemmer, P. Schov'anek, F. Schroder, A. Schulz, J. Schulz, J. Schumacher, S. Sciutto, A. Segreto, M. Settimo, A. Shadkam, R. Shellard, I. Sidelnik, G. Sigl, O. Sima, A. Śmiałkowski, R. vSm'ida, G. Snow, P. Sommers, J. Sorokin, R. Squartini, Y. Srivastava, D. Stanca, S. Stanivc, J. Stapleton, J. Stasielak, M. Stephan, A. Stutz, F. Suarez, T. Suomijarvi, A. Supanitsky, M. Sutherland, J. Swain, Z. Szadkowski, O. Taborda, A. Tapia, A. Tepe, V. M. Theodoro, C. Timmermans, C. T. Peixoto, G. Toma, L. Tomankova, B. Tom'e, A. Tonachini, G. T. Elipe, D. T. Machado, P. Trávnícek, M. Trini, R. Ulrich, M. Unger, M. Urban, J. F. V. Galicia, I. Valiño, L. Valore, G. V. Aar, P. Bodegom, A. M. Berg, S. Velzen, A. V. Vliet, E. Varela, B. V. C'ardenas, G. Varner, R. Vasquez, J. R. V'azquez, R. V'azquez, D. Veberivc, V. Verzi, J. Vícha, M. Videla, L. Villaseñor, B. Vlcek, S. Vorobiov, H. Wahlberg, O. Wainberg, D. Walz, A. Watson, M. Weber, K. Weidenhaupt, A. Weindl, F. Werner, A. Widom, L. Wiencke, H. Wilczy'nski, T. Winchen, D. Wittkowski, B. Wundheiler, S. Wykes, L. Yang, T. Yapici, A. Yushkov, E. Zas, D. Zavrtanik, M. Zavrtanik, A. Zepeda, Y. Zhu, B. Zimmermann, M. Ziolkowski, Z. Zong, F. Zuccarello +463 moresemanticscholar +1 more sourceGathering preliminary data [PDF]
, 2017 Prior to any large-scale basic science or clinical research project being funded, it is important for researchers to gather preliminary data. This is essential for providing evidence for the feasibility of research projects and helping to design larger ...Kasivisvanathan, Veeru, Salji, Mark J., Winchester, Catherine L. +2 morecore +2 more sourcesTranscriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourcePARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi +13 morewiley +1 more source
