Results 81 to 90 of about 214,960 (327)
The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. [PDF]
, 2018 The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop.
Chen, Mingyi +5 more
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Advanced Biology, EarlyView.The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran +5 more
wiley +1 more source
Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging
Stem Cell Reports, 2014 Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence.
Hoi-Hung Cheung +5 more
doaj +1 more source
Social and medical aspects longevity [PDF]
, 2011 The article deals with the demographical problem's population aging, life expectancy, premature aging, are shown results on quality of life in countries in relation to different indexes, that form ...
Duque Kalderon, U. F. +3 more
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Current epigenetic aspects the clinical kidney researcher should embrace [PDF]
, 2017 Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J. +5 more
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Advanced Engineering Materials, EarlyView.This study investigates the bond quality of co‐extruded aluminum–titanium hybrid profiles, focusing on the lateral angular co‐extrusion (LACE) process. It examines how heat treatments (HT) affect intermetallic phase formation, bond strength, and material properties.
Norman Mohnfeld +9 more
wiley +1 more source
Experimental and Molecular Medicine, 2018 Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging.
Jin Young Lee +9 more
doaj +1 more source
Germline and somatic mtDNA mutations in mouse aging. [PDF]
PLoS ONE, 2018 The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans.
Hong Ma +14 more
doaj +1 more source
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway. [PDF]
, 2020 Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption and associated illnesses, yet its aging mechanisms remain unclear.
Chen, Ye-Guang +13 more
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Cellular senescence - its role in cancer and the response to ionizing radiation [PDF]
, 2011 © 2011 Sabin and Anderson; licensee BioMed Central Ltd. This article is available through the Brunel Open Access Publishing Fund. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http ...
Anderson, RM, Sabin, RJ
core +2 more sources