Results 131 to 140 of about 516,689 (292)

Penetrance of Pathogenic Genetic Variants Associated With Premature Ovarian Insufficiency

(Abstracted from Nat Med 2023;29:1692–1699)Premature ovarian insufficiency (POI), defined as the loss of ovarian activity and permanent cessation of menstruation occurring before age 40 years, affects 1% of women and is a leading cause of infertility. Up
Perry, John R.B., Day, Felix R., Wood, Andrew R., Prague, Julia K., Weedon, Michael N., Hawkes, Gareth, Mörseburg, Alexander, Baptista, Julia, Ong, Ken K., Murray, Anna, Wright, Caroline F., Mishra, Gita D., Stankovic, Stasa, Beaumont, Robin N., Shekari, Saleh, Kentistou, Katherine A., Hoffmann, Eva R., Gardner, Eugene J., Ruth, Katherine S.   +18 more
core   +1 more source

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Women with polycystic ovary syndrome (PCOS) exhibit a substantially increased risk of miscarriage, yet the underlying mechanisms remain inadequately understood. This study aimed to investigate whether specific gut microbial dysbiosis and metabolic disturbance are associated with and may potentially contribute to endometrial ...
Mengyu Jing, Xi Chen, Meiyan Jiang, Huiya Fang, Xiaoming Zhu, Xuejing Jin, Yonghui Jiao, Ningning Hou, Weiwei Gong, Aixia Liu   +9 more
wiley   +1 more source

The influence of environmental factors on premature ovarian insufficiency and ovarian aging

Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. They are both characterized by hypergonadotropic hypogonadism and infertility, and together affect about 1 in ...
Evangelinakis, Nikolaos, Geladari, Eleni V., Geladari, Charalampia V., Kontogeorgi, Adamantia, Peppa, Melpomeni, Papaioannou, Georgios-Konstantinos, Kalantaridou, Sophia   +6 more
core   +1 more source

Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice

Theranostics
Rationale: Currently, there are occasional reports of health problems caused by sleep deprivation (SD). However, to date, there remains a lack of in-depth research regarding the effects of SD on the growth and development of oocytes in females.
Jiamao Yan, Xiaoyuan Zhang, Kexin Zhu, Mubin Yu, Qingchun Liu, M. De Felici, Teng Zhang, Junjie Wang, Wei Shen   +8 more
semanticscholar   +1 more source

Association Between Blood Transfusion for Postpartum Haemorrhage and the Risk of Premature Ovarian Failure: A Nationwide Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate the association between postpartum haemorrhage (PPH) severity and the subsequent risk of premature ovarian failure (POF), with blood transfusion used as a marker of severe PPH: Design Nationwide population‐based retrospective cohort study. Setting Korean National Health Insurance Service (KNHIS) database.
Min‐A Kim, Ju Hyeong Son, Hyun‐Joo Seol, Min‐Jeong Oh, Geum Joon Cho, Young‐Han Kim   +5 more
wiley   +1 more source

Clinical Efficacy and Experimental Research Progress on Traditional Chinese Medicine Moxibustion Therapy in Ovarian Injury

Chinese Medicine and Natural Products
This review summarizes the clinical efficacy and experimental research of traditional Chinese medicine (TCM) moxibustion in the intervention of ovarian injury.
Houpeng Wang, Ning Zhang, Liping Zheng, Liaoliao Hu   +3 more
doaj   +1 more source

Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment

Journal of Ovarian Research
Premature ovarian insufficiency (POI) is a condition in which the quantity of follicles and the quality of oocytes gradually decrease. This results in an estrogen secretion disorder and abnormal follicle development, which can lead to related diseases ...
J. Cui, Ying Wang
semanticscholar   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Pregnancy Following Metabolic–Bariatric Surgery in a Woman With Potential Premature Ovarian Failure: A Case Report

Case Reports in Surgery
Premature ovarian insufficiency (POI) is associated with decreased ovulation in the precursor stage which leads to ovarian failure in the end stage. Metabolic–bariatric surgery (MBS) can improve women’s reproductive status, including the release of sex ...
Raheleh Moradi, Maryam Kashanian, Somayeh Mokhber, Abdolreza Pazouki   +3 more
doaj   +1 more source

Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy

Stem cell research & therapeutics
Premature ovarian insufficiency (POI) is a major cause of infertility. In this study, we aimed to investigate the effects of the combination of bone marrow mesenchymal stem cells (BMSCs) and moxibustion (BMSCs-MOX) on POI and evaluate the underlying ...
Ge Lu, Hong-Xiao Li, Zi-Wei Song, Jia Luo, Yan-liang Fan, Yao-Li Yin, Jie Shen, Mei-Hong Shen   +7 more
semanticscholar   +1 more source