Results 131 to 140 of about 21,998 (244)

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

The acute effect of two exercise modalities on neurocognitive responses in postmenopausal women: A randomized controlled trial

Experimental Physiology, EarlyView.
Abstract Menopause‐related cognitive decline, often worsened by vasomotor symptoms (VMS), might be mitigated by high cardiorespiratory fitness (CRF). Although acute exercise supports neurocognitive function, its effects vary by exercise and individual characteristics.
Morgane Le Bourvellec, Nathalie Delpech, Laurent Bosquet, Geoffroy Boucard, Carina Enea   +4 more
wiley   +1 more source

HEP14-activated PKC-ERK1/2 pathway boosts HEP14-empowered hADSCs for ovarian regeneration and functional restoration

Communications Biology
Premature ovarian insufficiency (POI) and age-related natural-aging ovarian insufficiency (ARNA-OI) pose pressing global health challenges, necessitating effective therapeutic strategies and a deep understanding of their underlying mechanisms. This study
Jiajia Sun, Qin Zhong, Kan Liu, Qili Sun, Chunan Lu, Yingtong Di, Lin Bai, Helen Picton, Bin Tang, Xiaojiang Hao, Liming Gui   +10 more
doaj   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how maternal health and nutrition shape gut microbiota via epigenetics to regulate embryonic development. It highlights microbiota‐embryo interactions, disruption by prenatal chemical exposures, and personalized nutrition for disease prevention, offering novel insights and therapeutic targets.
Shoulong Xu, Yanjiao Huang, Chenyue Hu, Wenli Ding, Zhenwei Pu, Qiang Li, Zhiliang Xu   +6 more
wiley   +1 more source

A genome-wide association study of early menopause and the combined impact of identified variants [PDF]

, 2017
Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women who postpone their first pregnancy
Arnold, Alice, Ashworth, Alan, Bergmann, Sven, Buring, Julie E., Burri, Andrea, Chanock, Stephen J., Chasman, Daniel I., Chen, Constance, Cornelis, Marilyn C., Corre, Tanguy, Couper, David J., Demerath, Ellen W., Esko, Tõnu, Fischer, Krista, Franceschini, Nora, Garcia, Melissa, Goodarzi, Mark O., Gudnason, Vilmundur, Hankinson, Susan E., Harris, Tamara, He, Chunyan, Hofman, Albert, Hu, Frank B., Hunter, David J., Jones, Michael, Kraft, Peter, Kutalik, Zoltan, Launer, Lenore, Laven, Joop S. E., Li, Guo, Lunetta, Kathryn L., Mangino, Massimo, Masciullo, Corrado, McKnight, Barbara, Metspalu, Andres, Milani, Lili, Montgomery, Grant W., Murabito, Joanne M., Murray, Anna, Newman, Anne B., Ong, Ken K., Orr, Nicholas, Perry, John R. B., Psaty, Bruce M., Ridker, Paul M., Rivadeneira, Fernando, Rose, Lynda M., Sala, Cinzia, Salumets, Andres, Schoemaker, Minouk, Spector, Tim D., Stefansson, Kari, Stolk, Lisette, Sulem, Patrick, Swerdlow, Anthony J., Thorsteinsdottir, Unnur, Toniolo, Daniela, Traglia, Michela, Uitterlinden, André G., Van Dam, Rob M., Vernon Smith, Albert, Visser, Jenny A., Vollenweider, Peter, Waeber, Gérard, Weedon, Michael N., Zhuang, Wei V.   +65 more
core  

Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis

Immunology, Volume 178, Issue 2, Page 209-217, June 2026.
Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay, Mariem Garci, Ahmed Baligh Laaribi, Nabil Mathlouthi, Imene Ouzari   +4 more
wiley   +1 more source

Quantification of SARM1 NADase Activity in Human Peripheral Blood Mononuclear Cells

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Proposed model for NAD+ metabolism in (A) control and (B) SARM1 activated PBMCs. In native form, 3‐AP and Vacor compete with NAM as an alternative substrate for NAMPT. This consequently decreases generation of NMN and biosynthesis of NAD+ is limited by both a reduction in precursor NMN and direct inhibition of NMNAT by Vacor‐MN and 3‐AP‐MN.
Lila F. Dabill, Ivana R. Shen, Jennifer M. Brazill, Alicia Neiner, Yo Sasaki, Erica L. Scheller   +5 more
wiley   +1 more source