Results 111 to 120 of about 534,216 (254)

Feasibility and mechanism study of human umbilical cord mesenchymal stem cells for the treatment of premature ovarian insufficiency

European Journal of Medical Research
Background Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian insufficiency that occurs before the age of 40 years in women and is characterized by menstrual abnormalities (amenorrhea, scanty menstruation), follicle stimulating ...
Peiling Wu, Yao Liu, Lu Peng, Shihuan Tang, Hongmei Zhang, Xianping Zhang   +5 more
doaj   +1 more source

Far‐field bioluminescent immune cell–mediated photodynamic therapy is limited by photon flux

Photochemistry and Photobiology, EarlyView.
Bioluminescent immune cell‐mediated photodynamic therapy uses tumor‐homing, luciferase‐expressing immune cells as internal light sources to activate photosensitizers in deep‐seated and/or micrometastatic tumors. Using both experiments and computational simulations, we find that this approach delivers insufficient far‐field energy to tumor cells to ...
Ji Tae Park, Sudip Timilsina, Rebecca C. Harman, Chi‐Yong Eom, Jeonghyun Oh, Qianqian Fang, Nozomi Nishimura, Chris B. Schaffer, Bryan Q. Spring   +8 more
wiley   +1 more source

Fragile x-associated premature ovarian failure in a large Turkish cohort: Findings of Hacettepe Fragile X Registry

, 2018
Objective: To determine frequency of fragile X associated premature ovarian insufficiency (FXPOI) among Turkish premutation ...
Simsek-Kiper, Pelin Ozlem, Boduroglu, Koray, Urel-Demir, Gizem, Tuncbilek, ERGÜL, Akgun-Dogan, Ozlem, ALİKAŞİFOĞLU, MEHMET, ÜTİNE, GÜLEN EDA, Alanay, YASEMİN, AKTAŞ, Dilek   +8 more
core   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Premature ovarian insufficiency in patients with galactosemia

Педиатрическая фармакология
Background. Galactosemia is a congenital disorder of carbohydrate metabolism caused by a defect in any of the enzymes of galactose metabolism. One of the long-term complications is premature ovarian insufficiency (POI), which is more common in patients ...
Irina V. Karachentsova, Elena V. Sibirskaya, Adelina A. Khairullina   +2 more
doaj   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Elevated LH levels draw a stronger distinction than AMH in premature ovarian insufficiency

, 2014
Objectives A significant number of individuals have high serum follicle stimulating hormone (FSH) levels but do not meet the criteria for diagnosis of premature ovarian insufficiency (POI) due to ongoing menstruation.
Aydogan, B., Erel, T., Usta, T. A., Sahmay, S., Atakul, N.   +4 more
core   +1 more source

LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3175-3182, November 2026.
ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim, Janghan Lee, Seo‐Yeon Kim, Jihoon Kim, Moo Sun Hong   +4 more
wiley   +1 more source

Limb Compression Therapy and Chemotherapy‐Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self‐Controlled Study(NEURO‐GLOVE Trial)

International Journal of Cancer, Volume 159, Issue 9, Page 2300-2313, 1 November 2026.
With no effective drug‐based prevention strategies available for chemotherapy‐induced peripheral neuropathy (CIPN), research in neuroprotective approaches has grown. Of particular interest is mechanical compression, which may protect nerves by temporarily reducing blood flow during treatment. The authors here conducted a prospective trial in women with
Kadriye Başkurt, Galip Can Uyar, Enes Yeşilbaş, Fatma Zehra Altunç, Damla Erimhan Çevik, İsmet Murat Melek, Yasemin Eren, Ömür Berna Çakmak Öksüzoğlu, Kadriye Bir Yücel, Antonio Di Meglio, Isabelle Ray‐Coquard, Osman Sütcüoğlu   +11 more
wiley   +1 more source

The influence of environmental factors on premature ovarian insufficiency and ovarian aging

Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. They are both characterized by hypergonadotropic hypogonadism and infertility, and together affect about 1 in ...
Evangelinakis, Nikolaos, Geladari, Eleni V., Geladari, Charalampia V., Kontogeorgi, Adamantia, Peppa, Melpomeni, Papaioannou, Georgios-Konstantinos, Kalantaridou, Sophia   +6 more
core   +1 more source