Results 121 to 130 of about 13,204 (244)

Feasibility and mechanism study of human umbilical cord mesenchymal stem cells for the treatment of premature ovarian insufficiency

European Journal of Medical Research
Background Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian insufficiency that occurs before the age of 40 years in women and is characterized by menstrual abnormalities (amenorrhea, scanty menstruation), follicle stimulating ...
Peiling Wu, Yao Liu, Lu Peng, Shihuan Tang, Hongmei Zhang, Xianping Zhang   +5 more
doaj   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Reproductive outcomes in women with Hodgkin's lymphoma in a Danish fertility preservation cohort

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
The risk of premature ovarian insufficiency increases with the intensity of alkylating chemotherapy. In general, fertility outcomes were favorable, but chances of live birth decreased with increased intensity of alkylating chemotherapy. Ovarian tissue transplantation enabled natural conception in women with premature ovarian insufficiency, supporting ...
Lotte Berdiin Colmorn, Elisabeth C. Larsen, Anette Tønnes Pedersen, Stine Gry Kristensen, Kirsten Tryde Macklon   +4 more
wiley   +1 more source

Management of congenital female genital tract anomalies related to primary amenorrhea and/or cyclic abdominal pain: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Overall, 21 patients with uterine, cervical, and vaginal aplasia were treated successfully with neovagina formation. In 6 out of 8 patients, with obstructed uterine cavity, anastomosis was successful; one underwent hysterectomy and one elective hemi‐hysterectomy.
Grigoris F. Grimbizis, Sofia Tsiapakidou, Eirini Iordanidou, Georgios Kioussis, Anastasia Vatopoulou, Theodoros Theodoridis   +5 more
wiley   +1 more source

Gold‐standard evidence and best practice guidance for menstrual cycle‐informed clinical care: An overview for clinicians

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives To synthesize current evidence and provide clinically actionable recommendations for integrating menstrual cycle‐related processes—particularly hormone sensitivity, Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME)—into psychological assessment, formulation and treatment.
Ellen R. Lambert, Louise N. Nolan, Katja M. Schmalenberger   +2 more
wiley   +1 more source

AMH mutations with reduced in vitro bioactivity are related to premature ovarian insufficiency.

, 2015
Could anti-Müllerian hormone (AMH) mutations be implicated in the development of idiopathic premature ovarian insufficiency (POI)?SCOPUS: ar.jinfo:eu-repo/semantics ...
Imbert, Romain, De Leener, Anne, Englert, Yvon, Delbaere, Anne, Demeestere, Isabelle, Costagliola, Sabine, Alvaro Mercadal, Béatriz, Gervy, C   +7 more
core   +1 more source

Premature ovarian insufficiency in patients with galactosemia

Педиатрическая фармакология
Background. Galactosemia is a congenital disorder of carbohydrate metabolism caused by a defect in any of the enzymes of galactose metabolism. One of the long-term complications is premature ovarian insufficiency (POI), which is more common in patients ...
Irina V. Karachentsova, Elena V. Sibirskaya, Adelina A. Khairullina   +2 more
doaj   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Cardiovascular disease risk in women with premature ovarian insufficiency: A systematic review and meta-analysis

, 2016
Aims The purpose of this review was to assess the relationship between premature ovarian insufficiency (POI), defined as natural menopause 3 years, assessment of age ...
Heida, Karst Y., Roeters van Lennep, Jeanine; id_orcid, van Lennep, Jeanine E. Roeters, Bots, ML, Roeters van Lennep, Jeanine, Hoek, Annemieke, Bots, Michiel L., Hoek, A, Roeters Van Lennep, Jeanine E., Heida, KY   +9 more
core   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source