Results 101 to 110 of about 534,216 (254)

The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency

Molecular Genetics & Genomic Medicine
Background Premature ovarian insufficiency (POI) is a condition in women characterized by the premature decline of ovarian function before age 40, evident through menstrual irregularities such as amenorrhea or oligomenorrhea, elevated FSH levels ...
Hui Gao, Xi‐Xia Cao, Hua Hua, Hui Zhu
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Intraovarian injection of securinine stimulates the growth of small ovarian follicles by reducing stromal suppression

Nature Communications
The lack of hormone-responsive follicles is a major challenge in treating infertility/subfertility in women with premature ovarian insufficiency or diminished ovarian reserve.
Yu Zhao, Dongteng Liu, Zexiong Lin, Shuzi Deng, Xudong Zhao, Yiting Sun, Yihui Zhang, Qiong Zhang, Jingkai Gu, Yuan Xiao, Tianren Wang, Haonan Lu, Jing Zhao, Karen K. L. Chan, Yu Li, William S. B. Yeung, Kui Liu   +16 more
doaj   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

No Female Germline Stem Cells Were Identified by Advanced Dual Recombinase‐Based Lineage Tracing System

Cell Proliferation, EarlyView.
Schematic summary of the dual‐recombinase lineage tracing strategies to determine whether female germline stem cells (fGSCs) exist and sustain the ovarian follicle pool in adult female mice. Our study concluded that no fGSCs exist and contribute to oocyte regeneration in adult female mice with different tracing systems. ABSTRACT Whether female germline
Yang Gao, Zhiming Shen, Xiuhong Cui, Min Chen, Mengyue Wang, Kui Liu, Fei Gao, Hongmei Wang   +7 more
wiley   +1 more source

Clinical Efficacy and Experimental Research Progress on Traditional Chinese Medicine Moxibustion Therapy in Ovarian Injury

Chinese Medicine and Natural Products
This review summarizes the clinical efficacy and experimental research of traditional Chinese medicine (TCM) moxibustion in the intervention of ovarian injury.
Houpeng Wang, Ning Zhang, Liping Zheng, Liaoliao Hu   +3 more
doaj   +1 more source

Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy

The FEBS Journal, EarlyView.
As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley   +1 more source

Pregnancy Following Metabolic–Bariatric Surgery in a Woman With Potential Premature Ovarian Failure: A Case Report

Case Reports in Surgery
Premature ovarian insufficiency (POI) is associated with decreased ovulation in the precursor stage which leads to ovarian failure in the end stage. Metabolic–bariatric surgery (MBS) can improve women’s reproductive status, including the release of sex ...
Raheleh Moradi, Maryam Kashanian, Somayeh Mokhber, Abdolreza Pazouki   +3 more
doaj   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source