Results 91 to 100 of about 534,216 (254)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test [PDF]

Objectives: Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test.
Touwslager, Robbert N.H., Zwaan, C. Michel, Bakker, Boudewijn, Lentjes, Eef G.W.M., Looijenga, Leendert H.J., Van Santen, Hanneke M.   +5 more
core   +3 more sources

The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency

International Journal of Nanomedicine, 2015
Xiu-Ying Chen,1–3 Wu-Lian Chen,4 Min Ma,1–3 Chao Gu,1,2 Xi-Rong Xiao,1,2 Bin Li1,2 1Obstetrics and Gynecology Hospital, Fudan University, 2Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, 3Shanghai Key ...
Chen XY, Chen WL, Ma M, Gu C, Xiao XR, Li B   +5 more
doaj  

Premature ovarian insufficiency – to treat or not to treat?

Reproductive Endocrinology, 2019
Premature ovarian insufficiency (POI) is a rare but very damaging lifestyle condition that occurs at 1–1.5 of women and means termination of menstrual function up to 40 years old. POI impact on women’s wellbeing includes lipid metabolism dysregulation, haemostasis regulation changes, both leading to heart diseases risk increasing, psychological ...
O. S. Zahorodnia, I. B. Ventskivska, A. V. Kazak   +2 more
openaire   +5 more sources

Menopausal status at the age of 46: Its association with depressive and anxiety symptoms and morbidity in women—A northern Finland birth cohort 1966 study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Women who are perimenopausal or menopausal at age 46 have a higher risk of anxiety and depressive symptoms than premenopausal women. Early‐onset menopause highlights the need for mental health support during and after the menopausal transition. Abstract Introduction The incidence of several morbidities increases during the menopausal transition ...
Tiia Saarinen, Susanna M. Savukoski, Paula Pesonen, Jouko Miettunen, Maarit Niinimäki   +4 more
wiley   +1 more source

The PCOS‐to‐PMOS shift in the broader history of nomenclature changes and its uncertain impact on clinical practice

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Proposed renaming of polycystic ovary syndrome (PCOS) to polyendocrine metabolic ovarian syndrome (PMOS) aims to broaden multidisciplinary care. However, it may obscure reproductive manifestations and introduce phenotypic ascertainment bias. Historical examples of nomenclature changes suggest that clinical benefits depend heavily on diagnostic ...
Elina Aleksejeva‐Zagura, Piotr Laudański, Ganesh Acharya, Andres Salumets   +3 more
wiley   +1 more source

Penetrance of Pathogenic Genetic Variants Associated With Premature Ovarian Insufficiency

(Abstracted from Nat Med 2023;29:1692–1699)Premature ovarian insufficiency (POI), defined as the loss of ovarian activity and permanent cessation of menstruation occurring before age 40 years, affects 1% of women and is a leading cause of infertility. Up
Perry, John R.B., Day, Felix R., Wood, Andrew R., Prague, Julia K., Weedon, Michael N., Hawkes, Gareth, Mörseburg, Alexander, Baptista, Julia, Ong, Ken K., Murray, Anna, Wright, Caroline F., Mishra, Gita D., Stankovic, Stasa, Beaumont, Robin N., Shekari, Saleh, Kentistou, Katherine A., Hoffmann, Eva R., Gardner, Eugene J., Ruth, Katherine S.   +18 more
core   +1 more source

Gold‐standard evidence and best practice guidance for menstrual cycle‐informed clinical care: An overview for clinicians

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives To synthesize current evidence and provide clinically actionable recommendations for integrating menstrual cycle‐related processes—particularly hormone sensitivity, Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME)—into psychological assessment, formulation and treatment.
Ellen R. Lambert, Louise N. Nolan, Katja M. Schmalenberger   +2 more
wiley   +1 more source

Premature ovarian insufficiency: a syndrome or diagnosis

Репродуктивная эндокринология, 2017
The article presents modern views on the etiology, pathogenesis, diagnosis and management of premature ovarian insufficiency (POI) – syndrome which is heterogeneous in the etiology and pathogenesis and has a significant negative impact not only on the ...
Т. Ф Татарчук, Н. В. Косей, Т. Н. Тутченко   +2 more
doaj   +1 more source

The leukaemia in pregnancy study, a national multicentre retrospective study of pregnancy outcomes in women with concurrent or historic diagnoses of acute leukaemia

British Journal of Haematology, EarlyView.
Summary The leukaemia in pregnancy study was a multicentre retrospective study of pregnancy outcomes of women with concurrent (CAL) or previous (PAL) acute leukaemia. Cases were identified from eight hospitals. Of 39 screened cases, 12 CAL and 21 PAL cases were described, with one belonging to both groups.
Lukas Pitel, Matthew Northgraves, Judith Cohen, Chao Huang, John Turgoose, Simone Green, Steve Knapper, Gail Jones, Sarah Essex, Julie Kenny, Mhairi Copland, Panagiotis D. Kottaridis, Anjum Khan, Sahra Ali, David Allsup   +14 more
wiley   +1 more source