Results 71 to 80 of about 13,204 (244)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Premature Ovarian Insufficiency: Hormone Replacement Therapy and Follow-Up

, 2020
This chapter describes causes, diagnostic and therapeutic procedures in the event of premature ovarian insufficiency (POI) induced either by gonadotoxic treatments or caused by genetic defects, autoimmunological disease, infection, surgical interventions,
Stute, Petra, Volker Ziller, Ziller, Volker, von Wolff, Michael, Michael von Wolff, Petra Stute   +5 more
core   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Plasma metabolomic characterization of premature ovarian insufficiency

Journal of Ovarian Research, 2023
Background Premature ovarian insufficiency (POI) patients are predisposed to metabolic disturbances, including in lipid metabolism and glucose metabolism, and metabolic disorders appear to be a prerequisite of the typical long-term complications of POI ...
Xing-Yu Zhou, Xin Li, Jun Zhang, Ying Li, Xiao-Min Wu, Yi-Zhen Yang, Xiao-Fei Zhang, Lin-Zi Ma, Yu-Dong Liu, Zhe Wang, Shi-Ling Chen   +10 more
doaj   +1 more source

22q11.2 rearrangements found in women with low ovarian reserve and premature ovarian insufficiency

, 2018
International audienceOvarian reserve represents the number of available follicles/oocytes within ovaries and it can be assessed by follicle stimulating hormone levels, anti-Müllerian hormone levels, and/or antral follicle count determined by ultrasounds.
Guilhem Jouve, Elena J Tucker, Marion Beaumont, Marc-Antoine Belaud-Rotureau, Jouve, Guilhem, Laurent Pasquier, Tucker, Elena J, Mathilde Domin, Ravel, Célia, Odent, Sylvie, Sylvie Odent, Jaillard, Sylvie, Sylvie Jaillard, Belaud-Rotureau, Marc-Antoine, Domin, Mathilde, Pasquier, Laurent, Linda Akloul, Célia Ravel, Beaumont, Marion, Akloul, Linda   +19 more
core   +1 more source

Better 10‐Year Cerebrovascular Outcome After Transplant Than on Standard‐Care in Sickle Cell Anemia: DREPAGREFFE Trial

American Journal of Hematology, EarlyView.
ABSTRACT Management of cerebral vasculopathy in sickle cell anemia (SCA) includes standard‐care, that is, chronic transfusion (CT) or hydroxyurea, and hematopoietic cell transplantation (HCT). DREPAGREFFE‐1 (December 2010/June 2013), a French multicenter trial, was the first prospective trial comparing standard‐care to match sibling donor (MSD)‐HCT in ...
Francoise Bernaudin, Suzanne Verlhac, Elisabeth Ducros‐Miralles, Cécile Arnaud, Isabelle Genty, Marie Petras, Catherine Paillard, Gonzalo De Luna, Benoit Meunier, Isabelle Thuret, Annie Kamdem, Corinne Pondarré, Giovanna Cannas, Christelle Chantalat‐Auger, Nadia Firah, Sophie Pertuisel, Laure Joseph, Florence Missud, Mariane de Montalembert, Corinne Guitton, Claire Pluchart, Valentine Brousse, Monique Elmaleh, Vincent Gajdos, Emmanuella Leveillé, Ekaterina Belozertseva, Mabel Gaba, Catherine Poirot, Virginie Barraud‐Lange, Philippe Chadebech, France Pirenne, Myriam Bernaudin, Bénédicte Neven, Pierre Frange, Marie Angoso, Karima Yakouben, Bénédicte Bruno, Nathalie Dhédin, Jean‐Hugues Dalle, Regis Peffault Delatour, Camille Jung   +40 more
wiley   +1 more source

Expanding the Phenotype of TUFM‐Related Combined Oxidative Phosphorylation Deficiency 4

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier, Jodi Warman‐Chardon, Danielle K. Bourque   +2 more
wiley   +1 more source

Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT The present longitudinal study focuses on FMR1 premutation carrier women during midlife and early old age (n = 115). Bringing together the genetic risk factor of a family history of FXTAS and the environmental protective factor of higher education, the goal of the study was to determine how these factors potentially interact to predict self ...
Jinkuk Hong, Leann Smith DaWalt, Jessica Klusek, Elizabeth M. Berry‐Kravis, Marsha Mailick   +4 more
wiley   +1 more source

Gapo Syndrome: A New Syndromic Cause Of Premature Ovarian Insufficiency

, 2017
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Premature ovarian insufficiency has the following causes: genetic, autoimmune, metabolic, infectious, and iatrogenic dysfunctions (including radiotherapy, chemotherapy and surgery).
C. L.; Ferreira, D. A.; De Meho, V.; Andrade, Benetti-Pinto, L.; Yela, M. P.   +5 more
core   +1 more source

Supplemental information from: "Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing"

, 2022
Supplemental information from: "Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing"
Qian Zhang (12777767)
core   +1 more source