Results 51 to 60 of about 13,204 (244)

Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency

Reproductive Biology and Endocrinology, 2022
Background Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and premature ovarian insufficiency.
Fatemeh Afkhami, Shirin Shahbazi, Laya Farzadi, Shahla Danaei   +3 more
doaj   +1 more source

TP63-truncating variants cause isolated premature ovarian insufficiency [PDF]

, 2019
Premature ovarian insufficiency involves amenorrhea and elevated follicle-stimulating hormone before age 40, and its genetic basis is poorly understood. Here, we study 13 premature ovarian insufficiency (POI) patients using whole-exome sequencing.
Touraine, P, Sadedin, S, Jaillard, S, van den Bergen, J, Hanna, C, Sinclair, AH, Tucker, EJ, Grover, SR, Bell, KM, Robevska, G, Dulon, J   +10 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Associations Between BMI, Serum Hormone Levels, Time Since Ovarian Insufficiency Onset, Serologic Autoimmunity, and Prevalence of Common Parameters: A cross-sectional Retrospective Study of Premature Ovarian Insufficiency

Biomedical Sciences and Clinical Medicine, 2023
OBJECTIVE Premature ovarian insufficiency (POI) affects 1:100 women before the age of 40. The objectives include exploring correlations between body mass index, years since the onset of premature ovarian insufficiency, follicular stimulating
Kitirat Techatraisak, Prasong Tanmahasamut , Suchada Indhavivadhana, Thanyarat Wongwananuruk, Manee Rattanachaiyanont , Chongdee Dangrat   +5 more
doaj   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Premature ovarian insufficiency: evaluation and management

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012
Impairment of ovarian function before the age of 40 years is defined as premature ovarian insufficiency (POI). Alteration of normal menstrual pattern is the commonest presentation of POI and two serum follicle stimulating hormone (FSH) measurements in ...
Karuppiah Dharshini, Noel P Somasundaram
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

Journal of Ovarian Research, 2020
In the context of a continuously increased delay of motherhood and of an increase of the incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive marker of the duration of the fertility window.
Anne-Julie Fattet, Simon Toupance, Simon N. Thornton, Nicolas Monnin, Jean-Louis Guéant, Athanase Benetos, Isabelle Koscinski   +6 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source