Results 51 to 60 of about 516,689 (292)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Associations Between BMI, Serum Hormone Levels, Time Since Ovarian Insufficiency Onset, Serologic Autoimmunity, and Prevalence of Common Parameters: A cross-sectional Retrospective Study of Premature Ovarian Insufficiency

Biomedical Sciences and Clinical Medicine, 2023
OBJECTIVE Premature ovarian insufficiency (POI) affects 1:100 women before the age of 40. The objectives include exploring correlations between body mass index, years since the onset of premature ovarian insufficiency, follicular stimulating
Kitirat Techatraisak, Prasong Tanmahasamut , Suchada Indhavivadhana, Thanyarat Wongwananuruk, Manee Rattanachaiyanont , Chongdee Dangrat   +5 more
doaj   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

Advancement of science
Premature ovarian insufficiency (POI), defined by early loss of ovarian activity before the age of 40 years, is the leading cause of infertility and systematic aging in women, posing a public health challenge worldwide.
Y. Shang, Yunjun Li, Di Han, Kun-Kang Deng, Wei Gao, Ming-Hua Wu   +5 more
semanticscholar   +1 more source

TP63-truncating variants cause isolated premature ovarian insufficiency [PDF]

, 2019
Premature ovarian insufficiency involves amenorrhea and elevated follicle-stimulating hormone before age 40, and its genetic basis is poorly understood. Here, we study 13 premature ovarian insufficiency (POI) patients using whole-exome sequencing.
Touraine, P, Sadedin, S, Jaillard, S, van den Bergen, J, Hanna, C, Sinclair, AH, Tucker, EJ, Grover, SR, Bell, KM, Robevska, G, Dulon, J   +10 more
core   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Premature Ovarian Insufficiency: Hormone Replacement Therapy and Follow-Up [PDF]

, 2020
This chapter describes causes, diagnostic and therapeutic procedures in the event of premature ovarian insufficiency (POI) induced either by gonadotoxic treatments or caused by genetic defects, autoimmunological disease, infection, surgical interventions,
Stute, Petra, Volker Ziller, Ziller, Volker, von Wolff, Michael, Michael von Wolff, Petra Stute   +5 more
core   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency

Biomedicines
Background: Intraovarian platelet-rich plasma (PRP) has emerged as a novel intervention at the intersection of reproductive medicine and regenerative biology.
Efthalia Moustakli, A. Potiris, Athanasios Zikopoulos, A. Zachariou, Spyridon Topis, P. Panagopoulos, E. Domali, P. Drakakis, S. Stavros   +8 more
semanticscholar   +1 more source

Premature ovarian insufficiency: evaluation and management

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012
Impairment of ovarian function before the age of 40 years is defined as premature ovarian insufficiency (POI). Alteration of normal menstrual pattern is the commonest presentation of POI and two serum follicle stimulating hormone (FSH) measurements in ...
Karuppiah Dharshini, Noel P Somasundaram
doaj   +1 more source

Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

Journal of Ovarian Research, 2020
In the context of a continuously increased delay of motherhood and of an increase of the incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive marker of the duration of the fertility window.
Anne-Julie Fattet, Simon Toupance, Simon N. Thornton, Nicolas Monnin, Jean-Louis Guéant, Athanase Benetos, Isabelle Koscinski   +6 more
doaj   +1 more source