Results 41 to 50 of about 21,998 (244)

Expression profiles of miR-23a and miR-146a in the peripheral blood of women with premature ovarian insufficiency

Einstein (São Paulo)
Objective This study aimed to analyze the expression profiles of miR-23a and miR-146a in women with premature ovarian insufficiency and to evaluate their value as biomarkers of the disease for early diagnosis and prognosis, as well as effective ...
Thérèse Rachell Theodoro, Rafael Bitelman Barreiro, Isabella Verdi Cunha, Bianca Bianco, Caio Parente Barbosa, Denise Maria Christofolini   +5 more
doaj   +1 more source

Recognizing menopause in women with amenorrhea induced by cytotoxic chemotherapy for endocrine-responsive early breast cancer. [PDF]

, 2012
Cytotoxic anticancer treatment may induce amenorrhea or menopause to a variable extent. These side effects may not only impair or impede fertility but also cause sexual dysfunction, bone loss, and menopausal symptoms, with a strikingly negative effect on
Appetecchia, M, Barnabei, A, Corsello, SM., De Vecchis, L, Strigari, L, Torino, F   +5 more
core   +1 more source

Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency

Reproductive Biology and Endocrinology, 2022
Background Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and premature ovarian insufficiency.
Fatemeh Afkhami, Shirin Shahbazi, Laya Farzadi, Shahla Danaei   +3 more
doaj   +1 more source

Associations Between BMI, Serum Hormone Levels, Time Since Ovarian Insufficiency Onset, Serologic Autoimmunity, and Prevalence of Common Parameters: A cross-sectional Retrospective Study of Premature Ovarian Insufficiency

Biomedical Sciences and Clinical Medicine, 2023
OBJECTIVE Premature ovarian insufficiency (POI) affects 1:100 women before the age of 40. The objectives include exploring correlations between body mass index, years since the onset of premature ovarian insufficiency, follicular stimulating
Kitirat Techatraisak, Prasong Tanmahasamut , Suchada Indhavivadhana, Thanyarat Wongwananuruk, Manee Rattanachaiyanont , Chongdee Dangrat   +5 more
doaj   +1 more source

Oligogenic basis of premature ovarian insufficiency: an observational study

Journal of Ovarian Research
Background The etiology of premature ovarian insufficiency, that is, the loss of ovarian activity before 40 years of age, is complex. Studies suggest that genetic factors are involved in 20–25% of cases.
Panpan Long, Le Wang, Hangjing Tan, Ruping Quan, Zihao Hu, Minghua Zeng, Ziheng Deng, Hualin Huang, Jonathan Greenbaum, Hongwen Deng, Hongmei Xiao   +10 more
doaj   +1 more source

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland, Henze, R., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +4 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. [PDF]

, 2018
An algorithm assessing the methylation levels of 353 informative CpG sites in the human genome permits accurate prediction of the chronologic age of a subject.
Bedard, Jenna, Landis, Jessica, Marin, Diego, Morin, Scott J., Scott, Richard T., Seli, Emre, Tao, Xin, Zhan, Yiping   +7 more
core   +1 more source

Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): Rationale and design of a multicenter cohort study [PDF]

, 2017
Background: Reproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD ...
Benschop, L. (Laura), Boersma, H. (Eric), Budde, R.P.J. (Ricardo), Fauser, B.C.J.M. (Bart), Franx, A. (Arie), Groot, C.J.M. (Christianne) de, Laven, J.S.E. (Joop), Lugt, A. (Aad) van der, Maas, A.H.E.M. (Angela H.E.M.), Meun, C. (Cindy), Moons, K.G.M. (Karel), Rijn, B.B. (Bas) van, Roeters van Lennep, J.E. (Jeanine), Roos-Hesselink, J.W. (Jolien), Steegers, E.A.P. (Eric), Velthuis, B.K. (Birgitta), Zoet, G.A. (Gerbrand A.)   +16 more
core   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source