Results 31 to 40 of about 516,689 (292)

BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency

Nature Communications, 2022
Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction that results in infertility. Here they show that BCN1 mutation results in premature ovarian follicle activation and atresia through dysregulation of ferroptosis.
Feixia Wang, Yifeng Liu, Feida Ni, Jiani Jin, Yiqing Wu, Yun Huang, Xiaohang Ye, Xilin Shen, Yue Ying, Jianhua Chen, Ruixue Chen, Yanye Zhang, Xiao Sun, Siwen Wang, Xiao Xu, Chuan Chen, Jiansheng Guo, Dan Zhang   +17 more
doaj   +1 more source

Activation of AKT/mammalian target of rapamycin signaling in the peripheral blood of women with premature ovarian insufficiency and its correlation with FMR1 expression

Reproductive Biology and Endocrinology, 2022
Background The protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway regulates early follicular activation and follicular pool maintenance in female germline cells.
Julia Rehnitz, Birgitta Messmer, Ulrike Bender, Xuan Phuoc Nguyen, Ariane Germeyer, Katrin Hinderhofer, Thomas Strowitzki, Edison Capp   +7 more
doaj   +1 more source

Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation [PDF]

, 2014
Background: Ovarian tissue cryopreservation with later reimplantation has been shown to preserve fertility in adult women, but this approach remains unproven and experimental in children and adolescents.
Edgar, Angela E, Anderson, Richard A, Wallace, W Hamish B, Smith, Alice Grove, Kelsey, Thomas W   +4 more
core   +1 more source

Spontaneous pregnancy in a patient with premature ovarian insufficiency – case report

Menopause Review, 2018
Diagnosis of premature ovarian insufficiency is usually sudden and distressful for the patient in terms of facing infertility. However, some patients with POI have intermittent ovarian activity with an overall 5% probability of pregnancy.
Anna Calik-Ksepka, Monika Grymowicz, Weronika Bronkiewicz, Aleksandra Urban, Kamil Mierzejewski, Ewa Rudnicka, Roman Smolarczyk   +6 more
doaj   +1 more source

Intraovarian platelet-rich plasma: current status

Middle East Fertility Society Journal, 2021
Background The successful use of PRP in regenerative medicine has led investigators to study its effect in the treatment of conditions like decreased ovarian reserve, poor responders, and premature ovarian insufficiency.
Aboubakr Mohamed Elnashar
doaj   +1 more source

Clinical and Genetic Investigation of Premature Ovarian Insufficiency Cases from Turkey

, 2021
Objective: Premature ovarian insufficiency is a lack of ovarian functions in patients younger than 40 years old. Genetic causes leading to accelerated follicle depletion may result in premature ovarian insufficiency.
Oral, Engin, Toksoy, Guven, Azami, Asli, Uyguner, Zehra Oya, Karaman, Birsen, Basaran, Seher, Sofiyeva, Nigar, Celik, Hale Goksever   +7 more
core   +1 more source

Premature ovarian failure [PDF]

, 2017
Premature ovarian failure (POF) is the term usually used to describe women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility. POF is a devastating diagnosis for reproductive-aged women. The clinical
Katarzyna Jankowska
core   +1 more source

Practical Prediction Model for Ovarian Insufficiency after Radiation

Revista Brasileira de Ginecologia e Obstetrícia, 2022
Objective The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation.
Gabriel Oliveira Bernardes Gil, Cassiano Asano, Warne Pedro de Andrade, Maria Luísa Braga Vieira Gil, Eduardo Batista Cândido, Marcos Regalin, Izabella Nobre Queiroz, Farley Soares Cantídio, Darly Gomes Soares Delfino, Agnaldo Lopes Silva-Filho   +9 more
doaj   +1 more source

Premature ovarian insufficiency in female adolescent and young adult survivors of non-gynecological cancers: a population-based cohort study

Reproductive Health, 2023
Plain language summary Premature ovarian insufficiency is the onset of premature menopause in individuals less than 40-years-old. Previous research has shown that there is a higher risk of premature ovarian insufficiency in adolescent and young adult ...
Sydney B. Flatt, Amanda Baillargeon, Chad McClintock, Jessica Pudwell, Maria P. Velez   +4 more
doaj   +1 more source

Ovarian tissue and oocyte cryopreservation prior to iatrogenic premature ovarian insufficiency.

, 2022
Gonadotoxic treatments like chemotherapy or radiotherapy and ovarian surgery may result in an accelerated depletion of the ovarian reserve and subsequent premature ovarian insufficiency.
Donnez, Jacques, Dolmans, Marie-Madeleine, Cacciottola, Luciana   +2 more
core   +1 more source