Results 141 to 150 of about 516,689 (292)

Feasibility and mechanism study of human umbilical cord mesenchymal stem cells for the treatment of premature ovarian insufficiency

European Journal of Medical Research
Background Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian insufficiency that occurs before the age of 40 years in women and is characterized by menstrual abnormalities (amenorrhea, scanty menstruation), follicle stimulating ...
Peiling Wu, Yao Liu, Lu Peng, Shihuan Tang, Hongmei Zhang, Xianping Zhang   +5 more
doaj   +1 more source

TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo

Antioxidants
Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by the abnormal alteration of hormone levels such as FSH and E2. POI causes infertility, severe daily life disturbances, and long-term health risks. However,
Chong Zhou, Dandan Li, Jin-Xia He, Tao Luo, Yiting Liu, Yue Xue, Jian Huang, Li-Ping Zheng, Jia Li   +8 more
semanticscholar   +1 more source

Elevated cardiovascular risk associated with hormone replacement therapy: A comprehensive analysis of reproductive factors and atherosclerotic cardiovascular disease outcomes in the UK Biobank cohort

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Among 170,250 UK Biobank women (2006–2024), ever HRT use was associated with higher incident ASCVD risk (adjusted HR 1.13, 95% CI 1.08–1.18), largely driven by ischemic stroke. Associations were stronger in women ≤45 years and during perimenopause. Mediation via sex hormones, inflammatory markers, or lipids was minimal (<2%).
Mengchun Wang, Can Zhang, Chunlai Yang, Baosen Meng, Xiaohui Li, Qian Huang, Baibing Mi   +6 more
wiley   +1 more source

Gold‐standard evidence and best practice guidance for menstrual cycle‐informed clinical care: An overview for clinicians

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives To synthesize current evidence and provide clinically actionable recommendations for integrating menstrual cycle‐related processes—particularly hormone sensitivity, Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME)—into psychological assessment, formulation and treatment.
Ellen R. Lambert, Louise N. Nolan, Katja M. Schmalenberger   +2 more
wiley   +1 more source

Premature ovarian insufficiency in patients with galactosemia

Педиатрическая фармакология
Background. Galactosemia is a congenital disorder of carbohydrate metabolism caused by a defect in any of the enzymes of galactose metabolism. One of the long-term complications is premature ovarian insufficiency (POI), which is more common in patients ...
Irina V. Karachentsova, Elena V. Sibirskaya, Adelina A. Khairullina   +2 more
doaj   +1 more source

Practice guideline on ovarian tissue cryopreservation and transplantation in the prevention and treatment of iatrogenic premature ovarian insufficiency.

Maturitas
Premature ovarian insufficiency (POI) refers to the decline of ovarian function before the age of 40. POI causes a reduction in or loss of female fertility, accompanied by different degrees of menopausal symptoms, which increases the risk of chronic ...
X. Ruan, Che Xu, Hefeng Huang, Bing-He Xu, Juan Du, Jiaojiao Cheng, F. Jin, M. Gu, Wei-Min Kong, Cheng-Hong Yin, Yu-Rui Wu, Qin-Jie Tian, Yunxia Cao, Rui-Fang Wu, Liangzhi Xu, Jing Jin, Yanglu Li, Yinmei Dai, R. Ju, F. Ma, Gang Wang, Wei Wei, Xiaojun Huang, Mao-Quan Qin, Yuan Lin, Yuan Sun, Rong Liu, Wei Zhang, Xiao-Dong Li, Lin Zou, Min Hao, Xiyang Ye, Fuling Wang, Yue Wang, Zhuo-Ying Hu, Yan-Hong Huang, T. Zhu, Caihong Yang, Jin-Ping Wang, Xiao-Min Yang, Rong Ni, Liqun Wang, Guangxia Luo, Ai-Ping Min, Siyou Zhang, Pei-Ling Li, Linghui Cheng, Lian-Shuo Li, Quanfang Jin, Dongmei Shi, Yan Li, F. Ren, Yanxiang Cheng, J. Niu, Ying Tian, A. Mueck   +55 more
semanticscholar   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Genetic insights into the complexity of premature ovarian insufficiency

Reproductive Biology and Endocrinology
Premature Ovarian Insufficiency (POI) is a highly heterogeneous condition characterized by ovarian dysfunction in women occurring before the age of 40, representing a significant cause of female infertility.
Linhang Nie, Xiaojie Wang, Song Wang, Zhidan Hong, Mei Wang   +4 more
semanticscholar   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Resveratrol-βcd inhibited premature ovarian insufficiency progression by regulating granulosa cell autophagy

Journal of Ovarian Research
The ovarian environment of premature ovarian insufficiency (POI) patients exhibits immune dysregulation, which leads to excessive secretion of numerous proinflammatory cytokines that affect ovarian function.
Bingbing Hu, X. Zheng, Wei Zhang
semanticscholar   +1 more source