Results 141 to 150 of about 21,624 (243)

A genome-wide association study of early menopause and the combined impact of identified variants [PDF]

, 2017
Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women who postpone their first pregnancy
Arnold, Alice, Ashworth, Alan, Bergmann, Sven, Buring, Julie E., Burri, Andrea, Chanock, Stephen J., Chasman, Daniel I., Chen, Constance, Cornelis, Marilyn C., Corre, Tanguy, Couper, David J., Demerath, Ellen W., Esko, Tõnu, Fischer, Krista, Franceschini, Nora, Garcia, Melissa, Goodarzi, Mark O., Gudnason, Vilmundur, Hankinson, Susan E., Harris, Tamara, He, Chunyan, Hofman, Albert, Hu, Frank B., Hunter, David J., Jones, Michael, Kraft, Peter, Kutalik, Zoltan, Launer, Lenore, Laven, Joop S. E., Li, Guo, Lunetta, Kathryn L., Mangino, Massimo, Masciullo, Corrado, McKnight, Barbara, Metspalu, Andres, Milani, Lili, Montgomery, Grant W., Murabito, Joanne M., Murray, Anna, Newman, Anne B., Ong, Ken K., Orr, Nicholas, Perry, John R. B., Psaty, Bruce M., Ridker, Paul M., Rivadeneira, Fernando, Rose, Lynda M., Sala, Cinzia, Salumets, Andres, Schoemaker, Minouk, Spector, Tim D., Stefansson, Kari, Stolk, Lisette, Sulem, Patrick, Swerdlow, Anthony J., Thorsteinsdottir, Unnur, Toniolo, Daniela, Traglia, Michela, Uitterlinden, André G., Van Dam, Rob M., Vernon Smith, Albert, Visser, Jenny A., Vollenweider, Peter, Waeber, Gérard, Weedon, Michael N., Zhuang, Wei V.   +65 more
core  

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Integrative Genomic Profiling of Pediatric Solid Tumors Reveals Clinically Relevant Variants and Chromosomal Arm Aneuploidies Signatures

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Pediatric malignancies have emerged as the leading cause of disease‐related mortality in children, exhibiting distinct etiological and molecular characteristics compared to adult cancers. Despite advances in genomic profiling, the molecular landscape of pediatric solid tumors, particularly in Chinese populations, remains ...
Bingxiao Yan, Jinhu Wang, Jieni Xiong, Shuangai Liu, Yinbing Tang, Ziqi He, Hujin Yan, Bize Guo, Chen Chen, Yijie Zhang, Qinfang Zhu, Jiabin Cai, Min He, Xuan Wu, Junqing Mao, Lifeng Zhang, Weizhong Gu, Zhu Zhu, Zheming Li, Rui Xiao, Qiang Shu, Gang Yu, Ting Tao   +22 more
wiley   +1 more source

Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo‐Oophorectomy in BRCA1/2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background As the data on BRCA1/2‐associated breast and ovarian cancer prevalence after prophylactic surgery has not been exhaustively investigated yet, we aimed to evaluate the cancer prevalence in a single center cohort of BRCA1 and BRCA2 carriers after conducting prophylactic mastectomy, as well as prophylactic bilateral salpingo ...
Sara Mendes, Maryam Yahiaoui‐Doktor, Eva Maria Fallenberg, Marion Kiechle, Sabine Grill   +4 more
wiley   +1 more source

Multigene Germline Panel Testing in Gastric Cancer Patients in a Portuguese Population

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Gastric cancer is a heterogeneous disease with both environmental and genetic determinants. While Multigene Germline Panel Testing (MGPT) increasingly reveals hereditary predisposition, the prevalence and clinical significance of germline variants in Portuguese gastric cancer patients tested through institutional MGPT programs ...
B. Mourato, B. Cordeiro, F. Costa Pinto, N. Pratas, I. Fronteira, M. Areia, R. Dinis   +6 more
wiley   +1 more source

Ectocervical Hypergranulation Secondary to Transcervical Coil Thread Perforation—An Unusual Cause for Persistent Postcoital Bleeding

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Cervical perforation by coil threads is an uncommon complication. Predisposing factors may include prior cervical interventions, hypoestrogenic atrophy, thread material, and duration of use. Awareness is essential when evaluating abnormal bleeding or atypical thread presentation despite radiologically correct placement.
Negin Sadeghi, Karin Hellner
wiley   +1 more source

Shared Versus Unique Features of Neural Activation During Cognitive Flexibility Across Restrictive Eating Disorder Presentations

International Journal of Eating Disorders, Volume 59, Issue 3, Page 466-477, March 2026.
ABSTRACT Objective Restrictive eating disorders (EDs), including anorexia nervosa (AN) and atypical AN (Atyp‐AN), are often associated with cognitive rigidity that can impede treatment. The dorsolateral prefrontal cortex (dlPFC) plays a central role in cognitive control, but it remains unclear whether its activation during cognitive flexibility will ...
Adrienne L. Romer, Lauren Breithaupt, Meghan Slattery, Felicia Petterway, Lauren Lindman, Jason Scott, Meghan Lauze, Mia Cravitz, Zara Poon, Siddarth Seenivasa, Sarah Naticchia, Kristin N. Javaras, David Alperovitz, Jennifer J. Thomas, Elizabeth A. Lawson, Diego A. Pizzagalli, Franziska Plessow, Poornima Kumar, Madhusmita Misra, Kamryn T. Eddy   +19 more
wiley   +1 more source

PDMSA: A Web‐Based Tool for Pan‐Cancer Survival Analysis Using DNA Methylation Levels as Biomarkers

Advanced Genetics, Volume 7, Issue 1, March 2026.
PDMSA is a web‐based tool for exploring DNA methylation biomarkers across 39 cancer types. It integrates data from 8369 samples and performs survival analysis via Kaplan–Meier and Cox regression. With PDMSA, users can assess the impact of methylation on tumor survival outcomes, aiding the investigation of tumor development mechanisms.
Weiwei Guo, Ying Shi, Shanshan Wu, Hong Yang, Anqi Lin, Peng Luo   +5 more
wiley   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source