Results 51 to 60 of about 21,624 (243)

Cardiovascular RiskprofilE - IMaging and gender-specific disOrders (CREw-IMAGO): Rationale and design of a multicenter cohort study [PDF]

, 2017
Background: Reproductive disorders, such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and hypertensive pregnancy disorders (HPD) like pre-eclampsia (PE), are associated with an increased risk of cardiovascular disease (CVD ...
Benschop, L. (Laura), Boersma, H. (Eric), Budde, R.P.J. (Ricardo), Fauser, B.C.J.M. (Bart), Franx, A. (Arie), Groot, C.J.M. (Christianne) de, Laven, J.S.E. (Joop), Lugt, A. (Aad) van der, Maas, A.H.E.M. (Angela H.E.M.), Meun, C. (Cindy), Moons, K.G.M. (Karel), Rijn, B.B. (Bas) van, Roeters van Lennep, J.E. (Jeanine), Roos-Hesselink, J.W. (Jolien), Steegers, E.A.P. (Eric), Velthuis, B.K. (Birgitta), Zoet, G.A. (Gerbrand A.)   +16 more
core   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Premature ovarian insufficiency: evaluation and management

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012
Impairment of ovarian function before the age of 40 years is defined as premature ovarian insufficiency (POI). Alteration of normal menstrual pattern is the commonest presentation of POI and two serum follicle stimulating hormone (FSH) measurements in ...
Karuppiah Dharshini, Noel P Somasundaram
doaj   +1 more source

Optimizing Female Infertility in Premature Ovarian Insufficiency

Düzce Tıp Fakültesi Dergisi, 2022
Premature ovarian failure is a complex pathology with numerous etiologies and multiple system sequelae resulting for early deprivation of ovarian sex hormones. In the studies to determine the etiology, it is seen that many patients are in the unexplained
Pınar Çağlar Aytaç
doaj   +1 more source

Molecular cytogenetic analysis of Xq critical regions in premature ovarian failure. [PDF]

, 2013
BACKGROUND: One of the frequent reasons for unsuccessful conception is premature ovarian failure/primary ovarian insufficiency (POF/POI) that is defined as the loss of functional follicles below the age of 40 years.
Beke Artúr, Csomor Judit, Fekete György, Haltrich Irén, Karcagi Veronika, Matolcsy András, Pikó Henriett, Rigó János   +7 more
core   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Atualização em etiologia, diagnóstico e manejo da precocidade sexual [PDF]

, 2008
Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious puberty (GDPP) results from the premature activation of the hypothalamic ...
ARNHOLD, Ivo J. P., BRITO, Vinicius Nahime, LATRONICO, Ana Claudia, MENDONÇA, Berenice Bilharinho   +3 more
core   +2 more sources

Fresh insight into premature ovarian insufficiency

Ginekologia Polska, 2021
Premature ovarian insufficiency (POI) is one of the vital reasons of anovulatory infertility among women under 40 years old. However, because of the unacknowledged causative factor in most cases, it still remains a huge challenge in gynecology. Recently, the most promising opportunities in diagnosing are connected with the use of some serum biomarkers,
Paula, Karska, Aleksandra, Matonog, Paulina, Sieradzka, Karolina, Kowalczyk, Pawel, Madej   +4 more
openaire   +4 more sources

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Premature ovarian insufficiency: Pathogenesis and management

Journal of Mid-Life Health, 2015
The term premature ovarian insufficiency (POI) describes a continuum of declining ovarian function in a young woman, resulting in an earlier than average menopause. It is a term that reflects the variable nature of the condition and is substantially less
Anna J Fenton
doaj   +1 more source