Results 71 to 80 of about 67,518 (342)

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study

Pharmacology Research & Perspectives, 2022
Paclitaxel is a commonly used chemotherapeutic agent. To minimize the risk of hypersensitivity reactions (HSRs), which occur in approximately 16–42% of patients, premedication with dexamethasone, clemastine, and ranitidine was standard of care.
Anouk I. Haine, Cornelia (Marije) A. W. Notenboom, Liong (Vincent) P. Tan, Rikje Ruiter, Wendy M. van derDeure   +4 more
doaj   +1 more source

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer. Clinical results and biological observations in taxane-pretreated patients [PDF]

, 2015
Background: There is a deep need to improve the care of metastatic breast cancer (MBC) patients, since even today it remains an incurable disease. Taxanes are considered the most effective cytotoxic drugs for the treatment of MBC, both in monotherapy and
Caterino, M., Cognetti, F., De Vita, R., Fabi, A., Ferretti, G., Giannarelli, D., Iacorossi, L., Malaguti, P., Mottolese, Marcella., Nistico, C., Papaldo, P., Vari, S.   +11 more
core   +2 more sources

Use of PopPK and E‐R Analyses toward Explaining Causal Link Between ADAMTS13 in Recombinant vs. Plasma‐Based Therapies and Clinical Effects in cTTP

Clinical Pharmacology &Therapeutics, EarlyView.
Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, potentially life‐threatening condition caused by a deficiency of the blood enzyme ADAMTS13. Until now, ADAMTS13 replacement has been achieved with infusions of plasma or plasma‐based therapies (PBT).
Munjal Patel, Huijuan Xu, Olivier Barriere, Paul Diderichsen, Parth Patwari, Andy Z. X. Zhu, Jean François Marier, Thomas Peyret, Linda T. Wang, Björn Mellgård, Wenping Wang, Indranil Bhattacharya   +11 more
wiley   +1 more source

The comparison of gastric ph after premedication using ranitidine, antacids, and ranitidine-antacids combination in cesarean section

Bali Journal of Anesthesiology, 2020
Background: Pregnant women are at high risk of experiencing gastric fluid aspiration, which is known as Mendelson's syndrome. The possibility of aspiration increases in an emergency condition.
Ristiawan Muji Laksono, Isngadi Isngadi, Agung Hidayatullah   +2 more
doaj   +1 more source

Comparison of Efficacy of Clonidine versus Ondansetron for Prevention of Nausea and Vomiting Post Thyroidectomy: A Double Blind Randomized Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background and Aim: Postoperative nausea vomiting (PONV) is the most common symptom in patients post thyroidectomy. Literature search shows conflicting results regarding use of clonidine in PONV prophylaxis.
Setty Nagendra Gupta Shilpa, Sampangiramaiah Shailaja, Selvaraj Shanthini Hilda   +2 more
doaj   +1 more source

Randomized controlled trial assessing the effectiveness of midazolam premedication as an anxiolytic, analgesic, sedative, and hemodynamic stabilizer

Medicine, 2018
Background: Midazolam premedication is widely used before general anesthesia, but lacks clinical evidence of effectiveness. The present study aimed to evaluate the effectiveness of midazolam premedication following 4 aspects: anxiety reduction, sedation,
Soeun Jeon, H. Lee, Wangseok Do, Hae-Kyu Kim, J. Kwon, Boo-Young Hwang, Jihwan Yun   +6 more
semanticscholar   +1 more source

Revisiting intraperitoneal chemotherapy for advanced high‐grade serous ovarian cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare overall survival (OS) in patients with high‐grade serous ovarian cancer (HGSOC) treated with intraperitoneal (IP) chemotherapy versus intravenous (IV) chemotherapy. Methods A retrospective study of Stage III HGSOC with optimal primary cytoreduction during 2007–2019, followed by adjuvant IP or IV chemotherapy.
Joshua S Cheruvathur, Gabriel Levin, Reitan Ribeiro, Florentin Racovitan, Joanne Power, Xing Zeng, John Sampalis, Lucy Gilbert   +7 more
wiley   +1 more source

Limitations of the use of pressure waves to verify correct epidural needle position in dogs [PDF]

, 2013
The use of pressure waves to confirm the correct position of the epidural needle has been described in several domestic species and proposed as a valid alternative to standard methods, namely, control radiographic exam and fluoroscopy. The object of this
Adami, C, Bergadano, A, Spadavecchia, C
core   +3 more sources

Leveraging interprofessional team‐based care in an IBD clinic to transition patients from intravenous to subcutaneous risankizumab‐rzaa

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, EarlyView.
Abstract There are no data evaluating the success rate in transitioning intravenous (IV) to subcutaneous (SQ) risankizumab‐rzaa. To address these challenges, the University of Chicago Medicine (UCM) utilized an interprofessional team‐based, pharmacist‐directed follow‐up strategy to ensure patients initiate and maintain therapy.
David Choi, Marita Kametas, Jacqueline Gianni, Justin Han, David T. Rubin   +4 more
wiley   +1 more source