Results 41 to 50 of about 134,201 (266)
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
PLoS ONEBisphenols (BP), including BPA and "BPA-free" structural analogs, are commonly used plasticizers that are present in many plastics and are known endocrine disrupting chemicals. Prenatal exposure to BPA has been associated with negative neurodevelopmental
Samantha C Lauby +6 more
doaj +1 more source
Atmosphere, 2023 Informed by the theory of developmental origins of health and disease, we conducted a survey among 66,854 mother–preschooler dyads in all kindergartens within the Longhua District of Shenzhen in China for exploring the combined effect of prenatal ...
Yang Liang +5 more
doaj +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Prenatal methadone exposure and the developing brain [PDF]
, 2019 Opioid use globally is increasing resulting in rising numbers of pregnant women exposing their unborn babies to opioid drugs, with an estimated 30,000 children each year in Europe born to mothers who have used opioids during pregnancy.
Monnelly, Victoria J.
core +1 more source
Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source
Does a pint a day affect your child’s pay? The effect of prenatal alcohol exposure on adult outcomes [PDF]
This paper utilizes a Swedish alcohol policy experiment conducted in the late 1960s to identify the impact of prenatal alcohol exposure on educational attainments and labor market outcomes.
Nilsson, J Peter
core +2 more sources
Prenatal cadmium exposure and male infertility in mice: A multi-generational mechanistic study
Eco-Environment & HealthMale infertility affects approximately one in seven couples worldwide. Prenatal cadmium (Cd) exposure has been shown to affect offspring phenotypes and increase susceptibility to diseases later in life.
Hualong Zhu +13 more
doaj +1 more source
Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children
Environmental Health, 2017 Background Prenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social deficits in offspring.
Youn-Hee Lim +6 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 Childhood obesity and metabolic disorders are of concern and are public health problems globally. Environmental endocrine disruptors, including phthalates, are well known as “obesogens” and ''metabolic disruptors''.
Hui Gao +4 more
doaj +1 more source