Results 41 to 50 of about 28,499 (132)

Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research

Reproductive Medicine and Biology, 2022
Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive‐age women and has lifelong effects on health. Methods In this review, I discuss the pathophysiology of PCOS. First, I summarize our current understanding
Miyuki Harada
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Chronic Stress Alters Behavior in the Forced Swim Test and Underlying Neural Activity in Animals Exposed to Alcohol Prenatally: Sex- and Time-Dependent Effects

Frontiers in Behavioral Neuroscience, 2018
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) stress response has been suggested to play a role in vulnerability to stress-related disorders, such as depression.
Vivian Y. Y. Lam, Charlis Raineki, Lily E. Takeuchi, Linda Ellis, Todd S. Woodward, Todd S. Woodward, Joanne Weinberg   +6 more
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Prenatal exposure to adverse life events and autism and autistic‐like traits in children in the Norwegian Mother, Father and Child Cohort Study (MoBa)

JCPP Advances
Background Mothers' experience of adverse life events (ALEs, e.g., divorce, bereavement, injury) during pregnancy has been linked with neurodevelopmental conditions like autism, and related traits like social communication difficulties and repetitive ...
Aleksandra Kanina, Arvid Sjölander, Miriam I. Martini, Agnieszka Butwicka, Henrik Larsson, Amanda M. Hughes, Márta K. Radó, Mark J. Taylor, Alexandra Havdahl, Helga Ask, Mina A. Rosenqvist   +10 more
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Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol

Neurobiology of Disease, 2007
One of the most common causes of neurological disabilities are malformations of cortical development (MCD). A useful animal model of MCD consists of prenatal exposure to methylazoxymethanol (MAM), resulting in a postnatal phenotype characterized by ...
Stefania Bassanini, Kerri Hallene, Giorgio Battaglia, Adele Finardi, Stefano Santaguida, Marilyn Cipolla, Damir Janigro   +6 more
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Prenatal exposure to oral glucocorticoids and risk of long-term neurodevelopmental disorders

Scientific Reports
We investigated whether prenatal exposure to oral glucocorticoids (GCs) is associated with long-term neurodevelopmental disorders (LNDDs) in offspring.
Tak Kyu Oh, In-Ae Song
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Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

Frontiers in Molecular Neuroscience
IntroductionGiven the complex etiological basis of Alzheimer’s disease (AD), it is reasonable to hypothesize that neuronal dysfunction and death result from the interplay of numerous factors, both genetic and environmental.
Marta Matuszewska, Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Gabriela Olech-Kochańczyk, Ewelina Pałasz, Elżbieta Gawinek, Marcin Strawski, Grzegorz A. Czapski   +8 more
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Impact of chronodisruption during primate pregnancy on the maternal and newborn temperature rhythms. [PDF]

PLoS ONE, 2013
Disruption of the maternal environment during pregnancy is a key contributor to offspring diseases that develop in adult life. To explore the impact of chronodisruption during pregnancy in primates, we exposed pregnant capuchin monkeys to constant light (
María Serón-Ferré, María Luisa Forcelledo, Claudia Torres-Farfan, Francisco J Valenzuela, Auristela Rojas, Marcela Vergara, Pedro P Rojas-Garcia, Monica P Recabarren, Guillermo J Valenzuela   +8 more
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Paradoxical Effects of a Cytokine and an Anticonvulsant Strengthen the Epigenetic/Enzymatic Avenue for Autism Research

Frontiers in Cellular Neuroscience, 2020
Maternal exposure to the valproate short-chain fatty acid (SCFA) during pregnancy is known to possibly induce autism spectrum disorders (ASDs) in the offspring.
D. G. Béroule, D. G. Béroule
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A procedure for DNA methylation assessment in osteoporosis-related gene promoters of umbilical cord blood: A study on the Prospective Epidemiological Research Studies in Iran (PERSIAN) birth cohort [PDF]

BioImpacts
Introduction: It is believed that DNA methylation can modify disease susceptibility in response to environmental factors as early as the perinatal period.
Sadegh Baradaran Mahdavi, Seyed Morteza Javadirad, Mahsa Rafieian, Parnian Poursafa, Vajihe Azimian Zavareh, Seyede Shahrbanoo Daniali, Motahar Heidari-Beni, Masoomeh Goodarzi-Khoigani, Babak Vahdatpour, Hossein Mirhendi, Roya Kelishadi   +10 more
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Potential Mechanism Connecting Preeclampsia to Autism Spectrum Disorder in Offspring: The Role of Microglial Abnormalities

Frontiers in Bioscience-Landmark
Preeclampsia (PE) is a serious complication of pregnancy characterized by chronic inflammation and immune dysregulation, which significantly increases the risk of neurodevelopmental disorders in offspring, including the autism spectrum disorder (ASD ...
Ying Zhu, Si-Yi Wei, Xiao-Tong Fu, Xi Cheng, Xian-Hua Lin   +4 more
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