Results 71 to 80 of about 89,139 (298)

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Prenatal Maternal Stress and Preterm Birth: A Life Course Perspective [PDF]

, 2009
BACKGROUND: Prenatal maternal stress has been implicated in having a role in adverse health outcomes across the life span. Despite its potentially pervasive effects and population health significance, research examining the determinants of prenatal ...
Kingston, Dawn A.
core  

The role of prenatal posttraumatic stress symptoms among trauma exposed women in predicting postpartum depression

, 2021
Research suggests that a history of trauma and prenatal posttraumatic stress symptoms (PTSS) are predictive of postpartum depression (PPD). Pregnant women at risk for PPD are often identified through depression symptom measures, while PTSS also may help ...
Michelle L. Miller, Grekin, Rebecca, Rebecca Grekin, Thomas, Emily B. K., Miller, Michelle L., Michael W. O’Hara, Emily B. K. Thomas, Thomas, Emily B.K., O’Hara, Michael W.   +8 more
core   +1 more source

Prenatal exposure to escitalopram and/or stress in rats [PDF]

Psychopharmacology, 2013
A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother.The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate the effects on maternal care behavior.Female rats ...
Chase H, Bourke, Catherine F, Capello, Swati M, Rogers, Megan L, Yu, Katherine A, Boss-Williams, Jay M, Weiss, Zachary N, Stowe, Michael J, Owens   +7 more
openaire   +2 more sources

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Early-life heat stress exposure impacts dairy calf feeding and thermoregulatory behavior

JDS Communications, 2022
Heat stress has well-known influences on dairy calf physiology, but less is understood about calf behavioral responses to heat stress. Herein, we evaluated milk replacer intake, standing activity, and lying behaviors of calves exposed to prenatal or ...
Bethany Dado-Senn, Katie N. Gingerich, Kelsey C. Horvath, Sena L. Field, Marcela G. Marrero, Fiona Maunsell, Emily K. Miller-Cushon, Jimena Laporta   +7 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Chronic Prenatal Stress Affects Development And Behavioral Depression In Rats

, 2015
We have used the approach of Willner et al (1987), which consists of transitory and variable changes in the rat's living conditions, to investigate the influence of chronic prenatal stress on pup development and their susceptibility to behavioral ...
Teixeira N.A., Secoli S.R.
core   +1 more source

How Deep Are the Invisible Wounds? The Impact of Maternal Stress During Pregnancy on Adolescent Anxiety: A Cross-Sectional Study

NSC Nursing
Background: Pregnancy-related stress can affect a child’s development for a long time, increasing the likelihood of teenage anxiety. High levels of stress hormone exposure during pregnancy may interfere with the development of the nervous system and ...
Dessy Ekawati, Nurul Azmi Arfan, Esti Pratiwi Yosin, Endang Yuswatiningsih   +3 more
doaj   +1 more source