Results 81 to 90 of about 89,139 (298)
Frontiers in Physiology, 2022 Exposure to adverse childhood experiences or early life stress experiences (ELSs) increase the risk of non-adaptive behaviors and psychopathology in adulthood. Environmental enrichment (EE) has been proposed to minimize these effects.
K. Corredor +8 more
doaj +1 more source
Prenatal stress, glucocorticoids and the programming of adult disease [PDF]
Frontiers in Behavioral Neuroscience, 2009 Numerous clinical studies associate an adverse prenatal environment with the development of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk of psychiatric diseases in later life. Experimentally, prenatal exposure to stress or excess glucocorticoids in a variety of animal models can malprogram offspring physiology,
Cottrell, Elizabeth C.; id_orcid 0000-0002-0888-4707 +1 more
openaire +6 more sources
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
Epigenetic effects of prenatal stress on 11β-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain. [PDF]
PLoS ONE, 2012 Maternal exposure to stress during pregnancy is associated with significant alterations in offspring neurodevelopment and elevated maternal glucocorticoids likely play a central role in mediating these effects.
Catherine Jensen Peña +2 more
doaj +1 more source
Frontiers in Physiology, 2021 Fetal development is susceptible to environmental factors. One such factor is exposure to stress during pregnancy. The present study aimed to investigate the effects of chronic prenatal stress (PS) on the development and behavior of rat offspring during ...
Olga Abramova +12 more
doaj +1 more source
Steroid hormones, stress and the adolescent brain : a comparative perspective
, 2015 Steroid hormones, including those produced by the gonads and the adrenal glands, are known to influence brain development during sensitive periods of life.
Spencer, Karen Anne, Brown, Gillian Ruth
core +1 more source
Prenatal activation of toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring [PDF]
, 2012 Background - There is mounting evidence for a neurodevelopmental basis for disorders such as autism and schizophrenia, in which prenatal or early postnatal events may influence brain development and predispose the young to develop these and related ...
Stone, T.W. +5 more
core +1 more source
Prenatal Maternal Stress and the Risk of Asthma in Children [PDF]
Frontiers in Pediatrics, 2017 Emerging evidence indicate that maternal prenatal stress (MPS) can result in a range of long-term adverse effects in the offspring. The underlying mechanism of MPS is not fully understood. However, its complexity is emphasized by the number of purportedly involved pathways namely, placental deregulated metabolism of maternal steroids, impaired ...
Douros, K. +5 more
openaire +4 more sources
Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source
, 2017 Prenatal stress-induced neurobehavioral deficits observed in offspring are multifactorial, including oxidative stress in the developing brain. The time by which the developing brain acquires self-defense against oxidative stress is not clear.
Sampath Madhyastha +3 more
core +1 more source