Results 41 to 50 of about 1,421 (183)
Icaritin inhibits PD‐L1 expression by Targeting Protein IκB Kinase α
European Journal of Immunology, Volume 51, Issue 4, Page 978-988, April 2021., 2021 In this study, IKK‐α was identified as the protein target of Icaritin, by blocking the complex formation of IKK‐α/‐β, Icaritin inhibits NF‐κB p65 translocation and then downregulates PD‐L1 expression in tumor cells and immunosuppressive cells, which enhance the effect of immunotherapy. Abstract Icaritin, a small molecule currently being investigated in
Dongliang Mo +14 more
wiley +1 more source
Molecules, 2023 The phytochemical investigation of the roots of the traditional Chinese medicinal plant Sophora flavescens led to the isolation of two novel prenylflavonoids with an unusual cyclohexyl substituent instead of the common aromatic ring B, named 4′,4 ...
Yan-Fei Yang +5 more
doaj +1 more source
Disposition of hop prenylflavonoids in human breast tissue [PDF]
Molecular Nutrition & Food Research, 2010 AbstractHop‐derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8‐prenylnaringenin (8‐PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature of metabolites, and biodistribution were assessed and compared with 17β‐estradiol (E2) exposure.
Selin, Bolca +10 more
openaire +2 more sources
Regioselectivity during the palladium catalysed hydro-esterification of stilbenes and related alkenes [PDF]
, 2014 Ben C.B. Bezuidenhoudt +2 more
core +1 more source
Plant, Soil and Environment, 2002 The complete sequence hop gene, which corresponds to true chalcone synthase (EC 2.3.1.74), was amplified using a combination of PCR, RT PCR and inverse PCR methods and cloned from Czech Osvald's clone 72.
J. Matoušek +4 more
doaj +1 more source
Antiviral and antioxidant activity of a hydroalcoholic extract from Humulus lupulus L. [PDF]
, 2018 A hydroalcoholic extract from female inflorescences of Humulus lupulus L. (HOP extract) was evaluated for its anti-influenza activity. The ability of the extract to interfere with different phases of viral replication was assessed, as well as its effect ...
Carissimi, Stefania +12 more
core +1 more source
How wort boiling process affects flavonoid polyphenols in beer
Kvasný průmysl, 2019 Beer and brewing raw materials are a source of number of polyphenol substances with potential or proven beneficial biological effects. In pilot brews of Czech pale lager (200 l) the behavior of hop-derived polyphenol substances during wort boiling ...
Alexandr Mikyška, Martin Dušek
doaj +1 more source
Does canine inflammatory bowel disease influence gut microbial profile and host metabolism? [PDF]
, 2016 Background: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis.
Bosch, Guido +13 more
core +2 more sources
Molecules, 2018 Alzheimer’s disease (AD) is a serious threat for the aging society. In this study, we examined the preventive effect of the total prenylflavonoids (TPFB) prepared from the dried fruits of Psoralea corylifolia L., using an age-related AD mouse model SAMP8.
Zhi-Jing Chen +3 more
doaj +1 more source
The Association Between Urinary Genistein Levels and Mortality Among Adults in the United States [PDF]
, 2019 BackgroundCurrent research on the relationship between phytoestrogens and mortality has been inconclusive. We explored the relationship between genistein, a phytoestrogen, and mortality in a large cohort representative of the United States population ...
Marcelo, Carolyn +3 more
core +2 more sources