Results 141 to 150 of about 2,094 (191)

Preproenkephalin A-derived opioid peptides and mRNA of preproenkephalin A in human pheochromocytomas

Molecular and Cellular Endocrinology, 1987
Tissue contents of immunoreactive met-enkephalin (Met-Enk), leu-enkephalin (Leu-Enk) and met-enkephalin-Arg-Gly-Leu (Met-Enk-AGL) were determined by specific RIAs in 17 pheochromocytomas and the levels of preproenkephalin A mRNA were compared in some of these tissues by Northern blot hybridization.
Toshihiko Yanase, M Haji, H Ibayashi
exaly   +3 more sources

Distribution of preproenkephalin mRNA in the chicken and pigeon telencephalon

Journal of Comparative Neurology, 1994
AbstractBioassay and immunological studies have detected the presence of opioid peptides in the nervous system of representatives of all classes of vertebrates. The present study evaluates the expression and localization of preproenkephalin (PPE) mRNA to determine the sites of synthesis of the enkephalin peptides in the adult chicken and pigeon ...
MOLNAR M, CASINI, GIOVANNI, DAVIS BM, BAGNOLI, PAOLA, BRECHA N.   +4 more
openaire   +4 more sources

Preproenkephalin mRNA in T-Cells, macrophages, and mast cells

Journal of Neuroscience Research, 1987
AbstractThe presence of preproenkephaline mRNA in tumor cell lines derived from myeloid and mast cells was analyzed by RNA dot blot hybridization. A B‐cell lymphoma was negative for preproenkephalin mRNA, but several T‐cell lymphomas were positive.
J, Martin, M B, Prystowsky, R H, Angeletti   +2 more
exaly   +3 more sources

Isolation and structural organization of the human preproenkephalin B gene

Nature, 1983
The primary structure of porcine preproenkephalin B has been elucidated by cloning and sequencing cDNA: it contains neoendorphin, dynorphin and leumorphin (containing rimorphin as its amino-terminus). These opioid peptides, each having a leucine-enkephalin structure, act on the kappa-receptor.
Masaharu Noda, Toshiyuki Takai, Tai Kubo   +2 more
exaly   +3 more sources

Effect of Repeatedl-DOPA, Bromocriptine, or Lisuride Administration on Preproenkephalin-A and Preproenkephalin-B mRNA Levels in the Striatum of the 6-Hydroxydopamine-Lesioned Rat

Experimental Neurology, 1999
Abnormal involuntary movements, or dyskinesias, plague current symptomatic approaches to the treatment of Parkinson's disease. The neural mechanisms underlying the generation of dyskinesia following repeated l-3,4-dihydroxyphenylalanine (L-DOPA) or dopamine agonist administration in Parkinson's disease remain unknown. However, de novo administration of
Henry, Brian, Crossman, Alan R., Brotchie, Jonathan M.   +2 more
openaire   +3 more sources

Critical role of preproenkephalin in experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2006
Experimental autoimmune encephalomyelitis (EAE) is an organ-specific autoimmune disease model used to investigate mechanisms involved in the activation of self-reactive T cells. Preproenkephalin (PPNK) is the gene that encodes the protein proenkephalin A that has been detected in the brain, adrenal cells and cells of the immune system.
Catherine, Weir, Andrea, McNeill, Sarah, Hook, Marina, Harvie, Anne Camille, La Flamme, Graham, Le Gros, B Thomas, Bäckström   +6 more
  +7 more sources

Dopaminergic modulation of pallidal preproenkephalin mRNA

Molecular Brain Research, 1999
The present study examines dopaminergic regulation of neuropeptide gene expression within a relatively poorly characterized population of cells, the preproenkephalin (PPE) mRNA containing neurons of the globus pallidus (GP). Rats that received 6-hydroxydopamine (6-OHDA) lesions or repeated D1 or D2 antagonist administration were compared to control ...
J J, Schuller, L M, Billings, J F, Marshall   +2 more
openaire   +2 more sources

Preproenkephalin mRNA-expressing neurones in the rat thalamus

NeuroReport, 1995
We investigated the expression of preproenkephalin mRNA in the rat thalamus by in situ hybridization histochemistry using a radiolabelled full-length cRNA probe. Enkephalinergic neurones were present in the ventral thalamus, epithalamus, and intralaminar and midline nuclei of the dorsal thalamus.
O, Hermanson, M, Hallbeck, A, Blomqvist
openaire   +2 more sources

Effect of Lactation on Hypothalamic Preproenkephalin Gene Expression

Journal of Neuroendocrinology, 1995
AbstractEnkephalin appears to modulate several aspects of reproductive function in female rats. The purpose of this study was to determine if lactation influences preproenkephalin gene expression in one or more hypothalamic nuclei known to be involved in maternal or reproductive behavior and prolactin secretion. Lactating rats were killed on day 3 (LAC
M A, Ottinger, K L, Rosewell, N G, Weiland, K T, Margaretten, P M, Wise   +4 more
openaire   +2 more sources

Ontogeny of preproenkephalin mRNA expression in the rat retina

Visual Neuroscience, 1996
AbstractEndogenous opioid systems (i.e. opioid peptides and opioid receptors) modulate developmental events in the neonatal mammalian retina. In the present study, the mRNA encoding preproenkephalin A (PPE), the prohormone for the opioid growth factor (OGF), [Met5]-enkephalin, was studied in the developing and the adult retinas of rats.
T, Isayama, P J, McLaughlin, I S, Zagon
openaire   +2 more sources