Results 161 to 170 of about 2,094 (191)
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Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin
Nature, 1982The nucleotide sequence of cloned cDNA for preproenkephalin from bovine adrenal medulla indicates that the precursor protein contains four copies of Met-enkephalin and one copy each of Leu-enkephalin, Met-enkephalin-Arg6-Phe7 and Met-enkephalin-Arg6-Gly7-Leu8, a previously undetected opioid peptide.
M, Noda +7 more
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Region-specific regulation of preproenkephalin mRNA in cultured astrocytes
Molecular Brain Research, 1991Regulation of preproenkephalin (PPE) mRNA was examined in astrocytes cultured from several regions of the neonatal rat brain. Astrocytes from these regions expressed differing levels of PPE mRNA, with higher levels in astrocytes from the hypothalamus followed by frontal cortex and striatum.
D K, Batter, J A, Kessler
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Preproenkephalin B-derived opioid peptides in human phaeochromocytomas
Acta Endocrinologica, 1987Abstract. We demonstrated the presence and the secretion in vivo and in vitro of immunoreactive preproenkephalin B-derived opioid peptides (α-neoendorphin, dynorphin and leumorphin) in human phaeochromocytomas. In senventeen human phaeochromocytomas and two human adrenal medullas, the tissue contents of immunoreactive preproenkephalin B-derived opioid ...
T, Yanase +3 more
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Striatal changes in preproenkephalin mRNA levels in parkinsonian monkeys
NeuroReport, 1994Levels of preproenkephalin (PPE) mRNA were measured in different sectors of the striatum with in situ hybridization histochemistry in both normal and parkinsonian (MPTP-treated) squirrel monkeys. In parkinsonian monkeys, a marked increase in PPE mRNA levels was noted in the dorsolateral third of the precommissural putamen and in most of the ...
M C, Asselin +3 more
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Preproenkephalin mRNA expression in the developing and adult rat brain
Molecular Brain Research, 1994[Met5]-Enkephalin is derived from the protein precursor, proenkephalin A, which in turn is encoded by the preproenkephalin (PPE) gene. [Met5]-Enkephalin is not only a putative neuromodulatory substance, but also serves as a growth factor (= opioid growth factor, OGF). OGF exerts an inhibitory influence on the developing nervous system and is especially
I S, Zagon, T, Isayama, P J, McLaughlin
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Glucocorticoid regulation of preproenkephalin gene expression in the rat forebrain
Molecular Brain Research, 1992The effects of glucocorticoids on the levels of preproenkephalin (PPE) mRNA in the rat forebrain were analyzed with in situ hybridization and dot blots. In adrenally-intact rats, high levels of PPE mRNA, as assessed by in situ hybridization, were localized in the caudate-putamen, nucleus accumbens, central amygdala, and ventrolateral ventromedial ...
R S, Ahima, M M, Garcia, R E, Harlan
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Expression of Preproenkephalin mRNA and Production and Secretion of Enkephalins by Human Thymocytes
Annals of the New York Academy of Sciences, 2000Abstract: Human thymocytes were tested for the capacity to express the pre‐proenkephalin (PPE) gene and for production of the end product met‐enkephalin (MENK). It is shown here for the first time that the cytokines IL‐2, IL‐4, IL‐6, AND TGF‐β are capable of inducing PPE mRNA expression.
A, Kavelaars, C J, Heijnen
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Glucocorticoid Regulation of Preproenkephalin Messenger Ribonucleic Acid in the Rat Striatum*
Endocrinology, 1990Glucocorticoids regulate the level of preproenkephalin mRNA expression in a number of cell systems. This study investigated the expression of preproenkephalin mRNA in the brain and its regulation by glucocorticoids in vivo. Two different methods for mRNA quantitation were employed. Total RNA isolated from dissected brain tissue was analyzed in an RNAse
H M, Chao, B S, McEwen
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Transgenic Mice: Preproenkephalin and the Mu Opiate Receptor
Annals of the New York Academy of Sciences, 1996D M, Donovan +8 more
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Preproenkephalin mRNA enhanced by combination of droperidol with electroacupuncture.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995To study the expression of preproenkephalin (PPE) mRNA following electroacupuncture (EA) combined with droperidol (Dro), an antagonist of dopamine receptors.The brains of Sprague-Dawley rats were sectioned after combination of EA with Dro and nonradioactive in situ hybridization histochemistry (ISHH) technic was used.Ten hours after EA, the expression ...
C B, Zhu, X Y, Li, Y H, Zhu, S F, Xu
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