Results 151 to 160 of about 2,094 (191)

Localization of preproenkephalin a mRNA in the neonatal rat retina

Brain Research Bulletin, 1991
An opioid growth factor, [Met5]-enkephalin, is known to regulate developmental events in the neonatal rat retina. This growth factor interacts with the zeta (zeta) opioid receptor to modulate retinal ontogeny. Both peptide and receptor are present in developing retina, but not in adult retina.
T, Isayama, I S, Zagon
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Molecular Cloning and Characterization of the Hamster Preproenkephalin A cDNA

DNA and Cell Biology, 1994
The cDNA for hamster preproenkephalin A (ENK) was cloned from an adrenal gland cDNA library constructed in the lambda ZapII vector. A nearly full-length cDNA was obtained and its 5' end region was completed using the technique of rapid amplification of cDNA ends (RACE).
M, Beaulieu, M, Ouellette, L, Desgroseillers, L, Brakier-Gingras   +3 more
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Expression of the preproenkephalin A gene in the heart of cardiomyopathic hamsters

Biochemistry and Cell Biology, 1991
The expression of the preproenkephalin A gene (Enk gene), which codes for the precursor of enkephalins, was investigated in the heart of hamsters with a hereditary cardiomyopathy at four different stages of the disease: the prenecrotic stage (30 days), the necrotic stage (60 days), the hypertrophic stage (120 days), and the final stage (200 days).
M, Ouellette, M, Dumont, S, Lemaire, L, Brakier-Gingras   +3 more
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Chronic haloperidol treatment decreases preproenkephalin mRNA in the anterior pituitary: a study by solution-hybridization-RNase protection assay

Neuroscience Letters, 1996
By solution-hybridization-RNase protection assay, the preproenkephalin (PPek) mRNA in the anterior pituitary (AL) of male rats was found to decrease by 42% after 3 weeks haloperidol treatment.
S.M Lau, Tang, F, Lau, SM, F Tang
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Th2-dependent airway eosinophilia is regulated by preproenkephalin

Journal of Neuroimmunology, 2000
We have used preproenkephalin (PPNK)-deficient mice to study the role of PPNK in the development of airway inflammation. Airway eosinophilia was established by either sensitization followed by airway challenge with OVA or by infection with Nippostrongylus brasiliensis.
S, Hook, M, Prout, M, Camberis, M, Konig, A, Zimmer, G, Van Heeke, G, Le Gros   +6 more
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Preproenkephalin A Gene Expression in Rat Pineal

Neuroendocrinology, 2008
Preproenkephalin A (ppEnk) mRNA has been identified in extracts of rat pineal gland using oligonucleotides complementary to nonoverlapping regions of this mRNA. The mRNA has an apparent molecular size of 1.4 kb, equivalent to that found in rat brain.
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Absence of preproenkephalin increases the threshold for T cell activation

Journal of Neuroimmunology, 2003
Certain forms of the neuroendocrine hormone preproenkephalin (PPNK) are produced by T cells, B cells and macrophages. This hormone has been shown to be important in regulating a variety of immune responses; however, the basic mechanisms of this regulation are unknown.
Sarah, Hook, Mali, Camberis, Melanie, Prout, Graham, Le Gros   +3 more
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Inducible preproenkephalin DNA binding proteins in the rat striatum

Molecular and Cellular Neuroscience, 1991
The molecular manifestation of whole animal and cellular adaptive responses results from stimulus-secretion-synthesis coupling to selected genes. Effects are mediated through receptor-linked, signal-transduction pathways involving trans-acting nuclear proteins binding to cis-acting DNA regulatory elements. In the current report we have identified those
E F, La Gamma, G, Weisinger
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Cholinergic regulation of rat preproenkephalin RNA in the adrenal medulla

Molecular Brain Research, 1993
Expression of the rat preproenkephalin (ppENK) gene involves transsynaptic cholinergic mechanisms. We evaluated the effects of cholinergic agonist treatments in vivo on the expression of adrenomedullary ppENK RNA. Cholinergic treatment with nicotinic + muscarinic receptor agonists resulted in a synergistic 100-fold rise in steady-state ppENK messenger ...
J D, DeCristofaro, G, Weisinger, E F, LaGamma   +2 more
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Effect of nicotine use and withdrawal on brain preproenkephalin A mRNA

Brain Research, 1998
Although the effect of nicotine on brain neurotransmitters and behavior has been studied, the mechanism(s) by which nicotine contributes to tobacco use remains unclear. One transmitter that may relate to long-term nicotine use and its withdrawal is enkephalin, a five-amino acid opioid peptide derived from the proenkephalin A family.
A A, Houdi, R, Dasgupta, M S, Kindy
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