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Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks. [PDF]
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Preproenkephalin A-derived opioid peptides and mRNA of preproenkephalin A in human pheochromocytomas
Molecular and Cellular Endocrinology, 1987Tissue contents of immunoreactive met-enkephalin (Met-Enk), leu-enkephalin (Leu-Enk) and met-enkephalin-Arg-Gly-Leu (Met-Enk-AGL) were determined by specific RIAs in 17 pheochromocytomas and the levels of preproenkephalin A mRNA were compared in some of these tissues by Northern blot hybridization.
T, Yanase +4 more
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Dopaminergic modulation of pallidal preproenkephalin mRNA
Molecular Brain Research, 1999The present study examines dopaminergic regulation of neuropeptide gene expression within a relatively poorly characterized population of cells, the preproenkephalin (PPE) mRNA containing neurons of the globus pallidus (GP). Rats that received 6-hydroxydopamine (6-OHDA) lesions or repeated D1 or D2 antagonist administration were compared to control ...
J J, Schuller +2 more
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Critical role of preproenkephalin in experimental autoimmune encephalomyelitis
Journal of Neuroimmunology, 2006Experimental autoimmune encephalomyelitis (EAE) is an organ-specific autoimmune disease model used to investigate mechanisms involved in the activation of self-reactive T cells. Preproenkephalin (PPNK) is the gene that encodes the protein proenkephalin A that has been detected in the brain, adrenal cells and cells of the immune system.
Catherine, Weir +6 more
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Effect of Lactation on Hypothalamic Preproenkephalin Gene Expression
Journal of Neuroendocrinology, 1995AbstractEnkephalin appears to modulate several aspects of reproductive function in female rats. The purpose of this study was to determine if lactation influences preproenkephalin gene expression in one or more hypothalamic nuclei known to be involved in maternal or reproductive behavior and prolactin secretion. Lactating rats were killed on day 3 (LAC
M A, Ottinger +4 more
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Preproenkephalin mRNA-expressing neurones in the rat thalamus
NeuroReport, 1995We investigated the expression of preproenkephalin mRNA in the rat thalamus by in situ hybridization histochemistry using a radiolabelled full-length cRNA probe. Enkephalinergic neurones were present in the ventral thalamus, epithalamus, and intralaminar and midline nuclei of the dorsal thalamus.
O, Hermanson, M, Hallbeck, A, Blomqvist
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Preproenkephalin B-derived opioid peptides in human phaeochromocytomas
Acta Endocrinologica, 1987Abstract. We demonstrated the presence and the secretion in vivo and in vitro of immunoreactive preproenkephalin B-derived opioid peptides (α-neoendorphin, dynorphin and leumorphin) in human phaeochromocytomas. In senventeen human phaeochromocytomas and two human adrenal medullas, the tissue contents of immunoreactive preproenkephalin B-derived opioid ...
T, Yanase +3 more
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Th2-dependent airway eosinophilia is regulated by preproenkephalin
Journal of Neuroimmunology, 2000We have used preproenkephalin (PPNK)-deficient mice to study the role of PPNK in the development of airway inflammation. Airway eosinophilia was established by either sensitization followed by airway challenge with OVA or by infection with Nippostrongylus brasiliensis.
S, Hook +6 more
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Region-specific regulation of preproenkephalin mRNA in cultured astrocytes
Molecular Brain Research, 1991Regulation of preproenkephalin (PPE) mRNA was examined in astrocytes cultured from several regions of the neonatal rat brain. Astrocytes from these regions expressed differing levels of PPE mRNA, with higher levels in astrocytes from the hypothalamus followed by frontal cortex and striatum.
D K, Batter, J A, Kessler
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Preproenkephalin A Gene Expression in Rat Pineal
Neuroendocrinology, 1991Preproenkephalin A (ppEnk) mRNA has been identified in extracts of rat pineal gland using oligonucleotides complementary to nonoverlapping regions of this mRNA. The mRNA has an apparent molecular size of 1.4 kb, equivalent to that found in rat brain.
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