Results 161 to 170 of about 3,085 (184)

Preproenkephalin mRNA in T‐Cells, macrophages, and mast cells

Journal of Neuroscience Research, 1987
AbstractThe presence of preproenkephaline mRNA in tumor cell lines derived from myeloid and mast cells was analyzed by RNA dot blot hybridization. A B‐cell lymphoma was negative for preproenkephalin mRNA, but several T‐cell lymphomas were positive.
J, Martin, M B, Prystowsky, R H, Angeletti   +2 more
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Ontogeny of preproenkephalin mRNA expression in the rat retina

Visual Neuroscience, 1996
AbstractEndogenous opioid systems (i.e. opioid peptides and opioid receptors) modulate developmental events in the neonatal mammalian retina. In the present study, the mRNA encoding preproenkephalin A (PPE), the prohormone for the opioid growth factor (OGF), [Met5]-enkephalin, was studied in the developing and the adult retinas of rats.
T, Isayama, P J, McLaughlin, I S, Zagon
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Inducible preproenkephalin DNA binding proteins in the rat striatum

Molecular and Cellular Neuroscience, 1991
The molecular manifestation of whole animal and cellular adaptive responses results from stimulus-secretion-synthesis coupling to selected genes. Effects are mediated through receptor-linked, signal-transduction pathways involving trans-acting nuclear proteins binding to cis-acting DNA regulatory elements. In the current report we have identified those
E F, La Gamma, G, Weisinger
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Striatal changes in preproenkephalin mRNA levels in parkinsonian monkeys

NeuroReport, 1994
Levels of preproenkephalin (PPE) mRNA were measured in different sectors of the striatum with in situ hybridization histochemistry in both normal and parkinsonian (MPTP-treated) squirrel monkeys. In parkinsonian monkeys, a marked increase in PPE mRNA levels was noted in the dorsolateral third of the precommissural putamen and in most of the ...
M C, Asselin, J J, Soghomonian, P Y, Côté, A, Parent   +3 more
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Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin

Nature, 1982
The nucleotide sequence of cloned cDNA for preproenkephalin from bovine adrenal medulla indicates that the precursor protein contains four copies of Met-enkephalin and one copy each of Leu-enkephalin, Met-enkephalin-Arg6-Phe7 and Met-enkephalin-Arg6-Gly7-Leu8, a previously undetected opioid peptide.
M, Noda, Y, Furutani, H, Takahashi, M, Toyosato, T, Hirose, S, Inayama, S, Nakanishi, S, Numa   +7 more
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Cholinergic regulation of rat preproenkephalin RNA in the adrenal medulla

Molecular Brain Research, 1993
Expression of the rat preproenkephalin (ppENK) gene involves transsynaptic cholinergic mechanisms. We evaluated the effects of cholinergic agonist treatments in vivo on the expression of adrenomedullary ppENK RNA. Cholinergic treatment with nicotinic + muscarinic receptor agonists resulted in a synergistic 100-fold rise in steady-state ppENK messenger ...
J D, DeCristofaro, G, Weisinger, E F, LaGamma   +2 more
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Isolation and structural organization of the human preproenkephalin B gene

Nature, 1983
The primary structure of porcine preproenkephalin B has been elucidated by cloning and sequencing cDNA: it contains neoendorphin, dynorphin and leumorphin (containing rimorphin as its amino-terminus). These opioid peptides, each having a leucine-enkephalin structure, act on the kappa-receptor.
Saburo Horikawa, Toshiyuki Takai, Mitsuyoshi Toyosato, Hideo Takahashi, Masaharu Noda, Hitoshi Kakidani, Tai Kubo, Tadaaki Hirose, Seiichi Inayama, Hidenori Hayashida, Takashi Miyata, Shosaku Numa   +11 more
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Absence of preproenkephalin increases the threshold for T cell activation

Journal of Neuroimmunology, 2003
Certain forms of the neuroendocrine hormone preproenkephalin (PPNK) are produced by T cells, B cells and macrophages. This hormone has been shown to be important in regulating a variety of immune responses; however, the basic mechanisms of this regulation are unknown.
Sarah, Hook, Mali, Camberis, Melanie, Prout, Graham, Le Gros   +3 more
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Distribution of preproenkephalin mRNA in the chicken and pigeon telencephalon

Journal of Comparative Neurology, 1994
AbstractBioassay and immunological studies have detected the presence of opioid peptides in the nervous system of representatives of all classes of vertebrates. The present study evaluates the expression and localization of preproenkephalin (PPE) mRNA to determine the sites of synthesis of the enkephalin peptides in the adult chicken and pigeon ...
MOLNAR M, CASINI, GIOVANNI, DAVIS BM, BAGNOLI, PAOLA, BRECHA N.   +4 more
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Localization of preproenkephalin a mRNA in the neonatal rat retina

Brain Research Bulletin, 1991
An opioid growth factor, [Met5]-enkephalin, is known to regulate developmental events in the neonatal rat retina. This growth factor interacts with the zeta (zeta) opioid receptor to modulate retinal ontogeny. Both peptide and receptor are present in developing retina, but not in adult retina.
T, Isayama, I S, Zagon
openaire   +2 more sources