Results 171 to 180 of about 3,085 (184)

Preproenkephalin mRNA expression in the developing and adult rat brain

Molecular Brain Research, 1994
[Met5]-Enkephalin is derived from the protein precursor, proenkephalin A, which in turn is encoded by the preproenkephalin (PPE) gene. [Met5]-Enkephalin is not only a putative neuromodulatory substance, but also serves as a growth factor (= opioid growth factor, OGF). OGF exerts an inhibitory influence on the developing nervous system and is especially
I S, Zagon, T, Isayama, P J, McLaughlin
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Molecular Cloning and Characterization of the Hamster Preproenkephalin A cDNA

DNA and Cell Biology, 1994
The cDNA for hamster preproenkephalin A (ENK) was cloned from an adrenal gland cDNA library constructed in the lambda ZapII vector. A nearly full-length cDNA was obtained and its 5' end region was completed using the technique of rapid amplification of cDNA ends (RACE).
M, Beaulieu, M, Ouellette, L, Desgroseillers, L, Brakier-Gingras   +3 more
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Regulation of adrenomedullary preproenkephalin mRNA: effects of hypoglycemia during development

Molecular Brain Research, 1992
To further evaluate whether transsynaptic mechanisms account for stress-induced changes in adrenomedullary preproenkephalin mRNA (ppEnk mRNA), neonatal rats were made hypoglycemic at a time when synapses are non-functional (less than 10 days postnatal age).
E F, La Gamma, B L, Agarwal, J D, DeCristofaro   +2 more
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Preproenkephalin DNA-binding proteins in the rat: 5′ flanking region

Molecular Brain Research, 1989
Various extracellular signals (i.e. transmitters, hormones, growth factors, etc.), together with their respective second-messenger pathways, regulate transmitter biosynthesis and neuronal function by altering gene expression. In this study we validated a protocol for isolating rat striatum and adrenal medullary nuclei for the purpose of extracting ...
E F, La Gamma, N K, Goldstein, J B, Snyder, G, Weisinger   +3 more
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Glucocorticoid regulation of preproenkephalin gene expression in the rat forebrain

Molecular Brain Research, 1992
The effects of glucocorticoids on the levels of preproenkephalin (PPE) mRNA in the rat forebrain were analyzed with in situ hybridization and dot blots. In adrenally-intact rats, high levels of PPE mRNA, as assessed by in situ hybridization, were localized in the caudate-putamen, nucleus accumbens, central amygdala, and ventrolateral ventromedial ...
R S, Ahima, M M, Garcia, R E, Harlan
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“Binge” cocaine differentially alters preproenkephalin mRNA levels in guinea pig brain

Brain Research Bulletin, 2003
Male Hartley guinea pigs were administered i.p. injections of cocaine or saline for 2 or 7 days in a "binge" paradigm. RNA was isolated from dissected brain regions and levels of preproenkephalin mRNA and total RNA were quantified by RNase protection assays.
K Steven, LaForge, Vadim, Yuferov, Yan, Zhou, Ann, Ho, Fred, Nyberg, Mary, Jeanne Kreek   +5 more
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Leumorphin is a novel endogenous opioid peptide derived from preproenkephalin B

Biochemical and Biophysical Research Communications, 1983
Using synthetic leumorphin, we obtained antisera for leumorphin and set up two radioimmunoassays (RIAs) with different specificities. Gel exclusion chromatography coupled with the two RIAs showed the existence of a considerable amount of leumorphin-like peptide in water extracts from porcine neuro-intermediate pituitaries.
K, Nakao, M, Suda, M, Sakamoto, T, Yoshimasa, N, Morii, Y, Ikeda, C, Yanaihara, N, Yanaihara, S, Numa, H, Imura   +9 more
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Effect of nicotine use and withdrawal on brain preproenkephalin A mRNA

Brain Research, 1998
Although the effect of nicotine on brain neurotransmitters and behavior has been studied, the mechanism(s) by which nicotine contributes to tobacco use remains unclear. One transmitter that may relate to long-term nicotine use and its withdrawal is enkephalin, a five-amino acid opioid peptide derived from the proenkephalin A family.
A A, Houdi, R, Dasgupta, M S, Kindy
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Glucocorticoid Regulation of Preproenkephalin Messenger Ribonucleic Acid in the Rat Striatum*

Endocrinology, 1990
Glucocorticoids regulate the level of preproenkephalin mRNA expression in a number of cell systems. This study investigated the expression of preproenkephalin mRNA in the brain and its regulation by glucocorticoids in vivo. Two different methods for mRNA quantitation were employed. Total RNA isolated from dissected brain tissue was analyzed in an RNAse
H M, Chao, B S, McEwen
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SUBARACHNOID MORPHINE AFFECTS PREPROENKEPHALIN GENE EXPRESSION

Anesthesiology, 1989
G. Crosby, G. R. Uh1
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