Results 71 to 80 of about 11,160 (249)
Aging and disease, 2018 Presbycusis (age-related hearing loss) is the most universal sensory degenerative disease in elderly people caused by the degeneration of cochlear cells. Non-coding microRNAs (miRNAs) play a fundamental role in gene regulation in almost every multicellular organism, and control the aging processes.
Hu, Weiming +3 more
openaire +2 more sources
Aging Cell, Volume 25, Issue 1, January 2026.The illustration indicates that increased BST2 expression in Schwann cells leads to cochlear nerve demyelination, accelerating hearing loss in ARHL. The upregulation of BST2 reduces POU6F1 expression by activating the NF‐κB pathway, which impairs MPZ transcription and Schwann cell migration, ultimately contributing to neural demyelination in ARHL ...
Mengxiao Liu +8 more
wiley +1 more source
Anatomic correlates of strial presbycusis in recombinant inbred mouse strains [PDF]
, 2010 This project attempts to identify anatomic features that predict the range of the ‘normal’ endocochlear potential in young inbred mice. Cochlear lateral wall histologic metrics were compared in recombinant inbred (RI) mouse strains formed from BALB/c and
Walkonis, Christina M
core +1 more source
Audio-vestibular symptoms in systemic autoimmune diseases [PDF]
, 2018 Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss
Adelchi, Croce +7 more
core +1 more source
Indian Journal of Otology, 2021 Presbycusis is aging deafness, progressive decrease in hearing, high frequency usually associated with tinnitus. This is due to the release of free radicals in cellular metabolism leading to cell death of cochlear hair cells, stria vascularis, and sensorineural degeneration.
openaire +1 more source
Relación entre el déficit sensorial auditivo y depresión en personas mayores: revisión de la literatura [PDF]
, 2010 [Resumen] Los avances en las condiciones sanitarias y socioeconómicas de los países desarrollados han incrementado la esperanza de vida y el número de personas mayores. Sin embargo, aunque las condiciones sanitarias han mejorado, las alteraciones de la
García-Monasterio, Isabel +3 more
core +2 more sources
Journal of Comparative Neurology, Volume 533, Issue 12, December 2025.Symmetric and asymmetric synapses were significantly downregulated by 50% and 20%, respectively, in the aging inferior colliculus of the Alzheimer's 3xTG mouse model during the emerging disease stage (7–8 months). There was no additional significant loss from the emerging disease stage into the established disease stage.
Jeffrey G. Mellott +8 more
wiley +1 more source
Marginal cell density in young and old CBA/J and CBA/CAJ mice [PDF]
, 2009 The goal of the present study was to compare aging characteristics of the cochlear lateral wall in inbred mouse strains (CBA/J and CBA/CaJ) having very different endocochlear potential (EP)-versus-age profiles to see which anatomic differences might ...
Dahl, Ashley
core +1 more source
People and Nature, Volume 7, Issue 12, Page 3282-3296, December 2025.Abstract The human sensory systems are a primary means through which people experience and connect with nature. Understanding and improving people's personalised ecologies—their embodied, sensory interactions with other organisms—is key to addressing the causes and consequences of the extinction of experience and ecological grief prevalent in ...
Siddharth Unnithan Kumar +1 more
wiley +1 more source
Treating Hearing Loss: From Cochlear Implantation to Gene Therapy
Advanced Science, Volume 12, Issue 41, November 6, 2025.Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng +4 more
wiley +1 more source