In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2. [PDF]
Neuromolecular MedBegum S +4 more
europepmc +1 more source
Early-onset familial Alzheimer's disease in a family with mutation of presenilin 2 gene. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Li C, Xiao X, Wang J, Shen L, Jiao B.
europepmc +1 more source
Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer's disease. [PDF]
Acta NeuropatholOgg J +9 more
europepmc +1 more source
Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation. [PDF]
CNS Neurosci TherYoo SS +8 more
europepmc +1 more source
Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2. [PDF]
Sci Rep, 2018 Dhaliwal J +8 more
europepmc +1 more source
Case Report of a 63-Year-Old Patient With Alzheimer Disease and a Novel Presenilin 2 Mutation. [PDF]
Alzheimer Dis Assoc Disord, 2019 Wells JL, Pasternak SH.
europepmc +1 more source
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. [PDF]
Autophagy, 2019 Fedeli C +4 more
europepmc +1 more source
Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing. [PDF]
J Cell Mol Med, 2018 Stanga S +5 more
europepmc +1 more source
Expression, purification and biophysical characterization of human Presenilin 2
, 2013 Presenilin proteins are part of the γ-secretase complex which consists of four different membrane proteins. This complex plays an important role in the development of Alzheimer's disease. The cleavage of APP-C99 by $\gamma$-secretase generates the amyloid beta peptide which is the major component of amyloid plaques. Presenilins are considered to be the
openaire +1 more source
A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. [PDF]
J Cell Biol, 2016 Ezratty EJ, Pasolli HA, Fuchs E.
europepmc +1 more source