Results 111 to 120 of about 26,399 (217)

Presenilin 2 N141I Mutation Induces Hyperimmunity by Immune Cell-specific Suppression of REV-ERBα without Altering Central Circadian Rhythm. [PDF]

Exp Neurobiol, 2023
Nam H, Kim B, Lee Y, Choe HK, Yu SW.
europepmc   +1 more source

The Interface Between ER and Mitochondria: Molecular Compositions and Functions [PDF]

, 2018
Mitochondria and endoplasmic reticulum (ER) are essential organelles in eukaryotic cells, which play key roles in various biological pathways. Mitochondria are responsible for ATP production, maintenance of Ca2+ homeostasis and regulation of apoptosis ...
Lee, Soyeon, Min, Kyung-Tai
core   +1 more source

microRNA-183–5p induces cell density-dependent apoptosis through the regulation of Presenilin 2

European Journal of Cell Biology
Cells undergo apoptosis under dense culture condition to maintain homeostasis. Impaired apoptosis may contribute to the excessive accumulation of pathogenetic cells in such diseases as cancer and organ fibrosis.
Yuki Yabuuchi, Yosuke Matsuno, Kai Yazaki, Wei Zhen Ting, Kengo Nishino, Sosuke Matsumura, Kenya Kuramoto, Kazufumi Yoshida, Masashi Matsuyama, Takumi Kiwamoto, Yuko Morishima, Nobuyuki Hizawa   +11 more
doaj   +1 more source

Discovery and validation of autosomal dominant Alzheimer’s disease mutations

Alzheimer’s Research & Therapy, 2018
Background Alzheimer’s disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. Mutations in amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the pathogenic cause ...
Simon Hsu, Brian A. Gordon, Russ Hornbeck, Joanne B. Norton, Denise Levitch, Adia Louden, Ellen Ziegemeier, Robert Laforce, Jasmeer Chhatwal, Gregory S. Day, Eric McDade, John C. Morris, Anne M. Fagan, Tammie L. S. Benzinger, Alison M. Goate, Carlos Cruchaga, Randall J. Bateman, Dominantly Inherited Alzheimer Network (DIAN), Celeste M. Karch   +18 more
doaj   +1 more source

Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model. [PDF]

Front Neurol, 2023
Lehmann LM, Barker-Haliski M.
europepmc   +1 more source

Alzheimer's Disease: Genes, pathogenesis and risk prediction [PDF]

, 2001
With the aging of western society the contribution to morbidity of diseases of the elderly, such as dementia, will increase exponentially. Thorough preventative and curative strategies are needed to constrain the increasing prevalence of these disabling ...
Duijn, C.M. (Cornelia) van, Sleegers, K. (Kristel)   +1 more
core   +1 more source

Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury. [PDF]

Int J Biol Sci, 2023
Ma L, Liao L, Zhou N, Tao H, Zhou H, Tan Y, Chen W, Cao F, Chen X.   +8 more
europepmc   +1 more source

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor- and Cygb-associated signaling pathways

Neural Regeneration Research
A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer’s disease. Consequently, enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression ...
Biao Xiao, Chaoyang Chu, Zhicheng Lin, Tianyuan Fang, Yuyu Zhou, Chuxia Zhang, Jianghui Shan, Shiyu Chen, Liping Li   +8 more
doaj   +1 more source

Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer's Disease Mutations. [PDF]

Biochem Res Int, 2021
Soto-Ospina A, Araque Marín P, Bedoya GJ, Villegas Lanau A.   +3 more
europepmc   +1 more source

In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains. [PDF]

J Alzheimers Dis Rep, 2021
Barthelson K, Pederson SM, Newman M, Jiang H, Lardelli M.   +4 more
europepmc   +1 more source